Agent for preventing and treating skin diseases

Details Agent for preventing and treating skin diseases Agent for preventing and treating skin diseases

1999-10-14

2002-08-20

Fay, Zohreh (Department: 1614)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

C-o-group doai

Reexamination Certificate

active

06437002

ABSTRACT:

TECHNICAL FIELD
The present invention relates to an agent for preventing and treating skin diseases comprising an ascorbic acid derivative, a composition containing the agent and a preparation containing the agent, each of which has an effect of preventing and/or treating skin diseases and is employable in various forms such as a medical product, a quasi-drug and a cosmetic material.
BACKGROUND ART
Various agents for preventing and treating skin diseases, which have effects of preventing and/or treating skin diseases such as comedos, atopic skin diseases and wounds, have been developed heretofore.
The comedo is sometimes called pimple or acne vulgaris and means those having disorders or symptoms described in the following publication. That is, Kosho Kaishi (
Journal of Perfumes and Cosmetics
), Vol. 21, No. 4, page 341 (1997) describes comedos stating that “The comedo (acne) is a chronic inflammation disease attacking folliculus pili of sebaceous gland. This is generated predominantly at the age of puberty and a large number of intrinsic and extrinsic factors are complicatedly combined to form the cause of disease. With respect to the mechanism in the crisis of comedos, importance is attached to
Propionbacterium acnes
(hereinafter simply referred to as
P. acnes
). It is considered that irritation or destruction of the folliculus pili is brought about particularly in the process of inflammation from comedo to red papula, pustule, induration or cystoma by the action of various enzymes as a product of
P. acnes
, such as lipase, protease and hyaluronidase, or as a result of release of lysosome enzyme from neutrophiles reached folliculus pili due to a neutrotaxis factor produced from
P. acnes.”
The mechanism in the crisis of comedos is not yet clearly elucidated but sthenia of sebum cutaneum, sthenia in the keratinization of hair follicle, proliferation of bacteria and inflammation of hair follicle wall are considered to be main causes. Heretofore, comedos have been treated using a cream or ointment having blended thereto a sebum secretion inhibitor, a keratinization inhibitor (keratin abrasive), an antimicrobial or an antiinflammatory according to the cause. However, existing comedo treating agents having blended thereto a drug of various types have problems.
For example, the sebum secretion inhibitor used is a female hormone and the side effects brought about by the hormone agent raise serious problems. The keratinization inhibitor (keratine abrasive) includes a sulfur compound and a salicyclic acid and these are very problematic ingredients because of their excessive drying property or irritativesness. The antimicrobial includes chlorhexydine gluconate and benzalkonium chloride and these have a strong irritation and cause extreme chapping of the skin, thus, the effect cannot be satisfactorily brought out in the actual use.
The existing antiinflammatories have not yet succeeded in achieving satisfactory treatment of comedos. It is also considered to use a drug having a different action in combination and synergistically bring out the comedo treating effect, however, the synergistic effect obtained is not sufficient or side effects are synergistically caused. Thus, no effective combination of drugs for the comedo treatment has been attained. Moreover, even if the above-described drugs successfully treat comedos, comedo vestiges such as pigmentation or cratered skin impression remain for a long period of time and this causes a serious psychic problem particularly for young peoples at the age of puberty.
The combination use of an antimicrobial such as chlorhexydine gluconate or benzalkonium chloride and a sebum secretion inhibitor conventionally used in the treatment of comedos cannot attain a satisfactory synergistic effect as verified in the Comparative Example described later.
The atopic skin disease is one of allergic reactions. The allergic reactions are classified into Types I to IV by the mechanism in the action and various diseases are considered to occur due to secondary or composite participation of one or more of these Types. Out of these Types, Type I and Type IV, particularly Type IV, seem to participate in atopic skin diseases. Type I is sometimes called immediate allergy in which an antibody participates and Type IV is sometimes called delayed allergy in which cell-mediated immunity participates. Thus, these two Types greatly differ in the operation mechanism. Heretofore, for the treatment of atopic skin diseases, antihistaminics, steroid agents and the like have been used, however, antihistaminics having an effect only on Type I do not exhibit sufficiently high potency to atopic skin diseases and moreover, some cause adverse reaction affecting the center. Steroid agents having an effect also on Type IV exhibit high potency but due to their heavy adverse reaction, very great care is disadvantageously required on use of steroid agents. As such, a non-steroid type drug having effects on Type I and Type IV allergies, being low toxic and exhibiting excellent potency on atopic skin diseases has been keenly demanded.
The wound healing process in general can be classified into three overlapping stages. The first stage is a period of inflammation which takes place over the first three days after the tissue is injured. The second stage is a period of granule tissue formation which takes place in the term of 3 to 12 days after the injury. The third stage is a period of matrix formation and reorganization which take place in the term of about 3 to about 6 days after the injury. In the inflammation period, upon injuring of a tissue, blood ingredients are released into the wound region, whereby the coagulation cascade is activated and a matrix is provided against inflow of inflammable cells. Thereafter, formation of granule tissues starts such that new blood vessel systems embedded in a matrix generally known as an extracellular matrix (ECM) which is a loose matrix comprising fibroblast, macrophages, collagen, fibronectin and hyaluronic acid, are densely grouped to organize the granule tissue. The epithelial cell in the wound grows and new blood vessels are formed (vascularization) to supply nutrients and oxygen to the injured region. This supply of nutrients is indispensable for the synthesis, deposition and organization of ECM.
Within few hours after injury, re-epitheliarization starts to completely recover the injured surface. This matrix formation and reorganization stage is initiated at the same time of gradual lysis of granule tissues resulting from devascularization and involves disappearance of cells, fibronectin and type III collagen. The granule tissue is replaced by a connective tissue organized by a frame of a collagen and an elastin fibers which provide strength and elasticity to the tissue, respectively. This frame is then saturated with proteoglycans and glycoproteins. Thus, the reorganization is accompanied by synthesis of new collagen and decomposition of aged collagen. After the matrix formation and reorganization, scared tissues finally result.
Another most important aspect in the healing of a wound is the rate of the wound gaining a tensile strength. During the wound healing, the tensile strength increases in proportion to the increase of the collagen content in the wound. The increment of the tensile strength correlates to the collagen synthesis rate over the initial 10 weeks in the healing of a wound.
In many studies, it has been stressed that an ascorbic acid is a matter of importance in the healing of wounds. The ascorbic acid is concentrated at the wound to be healed and the circulation level thereof is abruptly reduced after the skin injury. Furthermore, the ascorbic acid is indispensable for the growth and maintenance of connective tissues. The ascorbic acid is a cofactor of several kinds of endogenous hydroxylases including propylhydroxylase and xylylhydroxylase which hydroxylate propyl in procollagen polypeptide and a lysyl residue to form hydroxyproline and hydroxylysine, respectively. The hydroxyproline is essential for the maximum stabilizatio

Affiliated with

Also associated with

Rating

Agent for preventing and treating skin diseases does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Agent for preventing and treating skin diseases, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Agent for preventing and treating skin diseases will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2902664