Compositions – Compositions containing a single chemical reactant or plural... – Inorganic reactant other than sulfur containing
Patent
1987-03-17
1988-09-27
Miller, Edward A.
Compositions
Compositions containing a single chemical reactant or plural...
Inorganic reactant other than sulfur containing
25218231, 25218212, 530419, 530420, C09G 300
Patent
active
047740191
ABSTRACT:
An apparatus is provided for reacting a solution of a precipitating medium of alkaline metal chlorides at a fixed rate of delivery with plasma continuously separated from blood, filtering the precipitate formed by the reaction, removing the solution of precipitating medium from the plasma following the use of the medium, adjusting the purified treated plasma, and returning the purified plasma to the blood in an amount equivalent to that of the continuously separated plasma. To enhance the precipitative separating action of alkaline metal chloride on plasma protein without detracting from the advantages of the alkaline metal chloride, use is made of a solution of precipitating medium comprising a mixture of the alkaline metal chloride and an amino acid, the latter being added in an amount sufficient to promote the precipitating effect of the alkaline metal chloride.
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patent: 4351710 (1982-09-01), Jain
patent: 4381775 (1983-05-01), Nose et al.
patent: 4401430 (1983-08-01), Dorson, Jr. et al.
patent: 4582598 (1986-04-01), Bilstud et al.
Chemical Abstracts, vol. 91, No. 19, Nov. 5, 1979, p. 300, ref. No. 153871p; Ohara et al: "Comparison of Protein Precipitants for the Determination of Free Amino Acids in Plasma".
Journal of Chromatography, vol. 226, pp. 455-460; Chrombio. 1033; J. Blanchard "Evaluation of the Relative Efficacy of Various Techniques for Deproteinizing Plasma Samples Prior to High-performance Liquid Chromatographic Analysis".
American Society for Artificial Internal Organs, vol. XXXI, Transactions, May 1-3, 1985 Atlanta, pp. 686-691; Saito et al: "A New Autologous Plasma Exchange System with Salt-Amino Acid Coprecipitation (SAC) Method".
Journal of the American Chemical Society, vol. 68, Mar. 1946, pp. 459-475, Cohn et al: "Preparation and Properties of Serum and Plasma Proteins, IV, A System for The Separation into Fractions of the Protein and Lipoprotein Components of Biological Tissues and Fluids 1a, b,c,d".
Ohe Hiroaki
Watanabe Masaharu
Miller Edward A.
Terumo Kabushiki Kaisha
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