Agent for potentiating nerve growth factor activity containing 1

Details Agent for potentiating nerve growth factor activity containing 1 Agent for potentiating nerve growth factor activity containing 1

1997-12-31

1999-10-19

Gupta, Yogendra N.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

5142372, 514255, 514336, 514422, A61K 31535, A61K 3144, A61K 31495, A61K 3140

Patent

active

059689358

ABSTRACT:
A 1,2-ethanediol derivative represented by the general formula [I] or its salt: ##STR1## has a NGF activity-potentiating effect and is useful as a remedy for various diseases caused by degeneration of central nervous system or peripheral nervous system such as senile dementia of Alzheimer type, Huntington's chorea, various neuropathies, Riley-Day syndrome, traumatic nerve injury, amyotrophic lateral sclerosis (ALS) and the like.

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Chemical Abstracts, vol. 119, No. 9, p. 72; column 2; XPOO2048283; Aug. 30, 1993 S. Ono, et al.: "Protective effect of R(-)-1- (benzo[b]thiophen-5-yl)-2-[2-(n,n-diethylamino)ethoxy] ethanol hydrichloride (T-588), a novel cerebral activator, against experimental cerbral anoxia."
Science, vol. 259, No. 5093 (1993), pp. 373-377.
Biomedical. Letter, vol. 48, No. 191 (1993), pp. 209-227.

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