Drug – bio-affecting and body treating compositions – Fermentate of unknown chemical structure
Patent
1977-09-06
1979-06-26
Tanenholtz, Alvin E.
Drug, bio-affecting and body treating compositions
Fermentate of unknown chemical structure
195 96, C12D 920, C07G 1100
Patent
active
041593219
ABSTRACT:
A process for preparing an antimalignant agent which comprises cultivating Staphylococcus epidermidis STF (Bikoken(or Microbic Industry Technological Institute)Deposit No. 3706; ATCC 31310) in a liquid culture medium, removing solid matter from the culture solution, concentrating the remaining solution, washing the precipitate thus formed with water, re-dissolving the precipitate, fractionating the solution into a number of fractions by an adsorptive filtration gel or the molecular sieve method, taking a fraction exhibiting antimalignant activity, concentrating the fraction, further purifying the fraction by ion-exchange chromatography and separating the active ingredient; and the antimalignant agent thus obtained.
REFERENCES:
patent: 3366540 (1968-01-01), Tendler
patent: 3625833 (1971-12-01), Schaffer
Fujita Haruhisa
Fujiwara Mikiro
Fukuma Mariko
Itoh Mie
Itoh Munemoto
Tanenholtz Alvin E.
Tobishi Pharmaceutical Co., Ltd.
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