Agent for inhibiting symmetrical proteins, in particular enzymes

Details Agent for inhibiting symmetrical proteins, in particular enzymes Agent for inhibiting symmetrical proteins, in particular enzymes

1996-01-11

1997-10-07

Davenport, Avis M.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

15 to 23 amino acid residues in defined sequence

530327, 530328, 530329, 530330, A61K 3800, C07K 500, C07K 700

Patent

active

056749791

ABSTRACT:
The invention relates to substances for the inhibition of symmetric proteins, in particular enzymes, in particular the inhibition of HIV protease, in the form of structurally symmetric or near symmetric enzyme inhibitors, chazacterized by the same symmetry, or approximate or piecewise (yet sufficient for inhibition) symmetry, as the enzyme molecule to be inhibited.

REFERENCES:
Pechik et al., FEBS LETT., vol. 247, No. 1, pp. 118-122, Apr. 1989.
Billish, S. et al., J. Biol. Chem. 263:17905-17908 (1988).

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