Agent for inducing conversion of intestinal cells into...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai

Reexamination Certificate

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C530S308000, C435S377000

Reexamination Certificate

active

07423019

ABSTRACT:
A partial peptide of a preproglucagon peptide comprising at least the amino acid sequence at positions92-97of a preproglucagon peptide is used as an effective ingredient of an antidiabetic drug.

REFERENCES:
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Anonymous, Harvard health letter / from Harvard Medical School, (May 2002) vol. 27, No. 7, p. 6.
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Bataille, D. et al. “Bioactive Enteroglucagon (Oxyntomodulin): Present Knowledge on Its Chemical Structure and Its Biological Activities”, Peptides, vol. 2 pp. 41-44, 1981.
Mojsov, S. et al. “Insulinotropin: Glucagon-like Peptide I (7-37) Co-encoded in the Glucagon Gene Is a Potent Stimulator of Insulin Release in the Perfused Rat Pancreas”,J. Clin. Invest., vol. 79 pp. 616-619, 1987.
Abraham, E.J. et al. “Insulinotropic Hormone Glucagon-Like Peptide-1 Differentiation of Human Pancreatic Islet-Derived Progenitor Cells into Insulin-Producing Cells”,Endocrinology, vol. 143(8) pp. 3152-3161, 2002.
Gutniak, M. et al. “Antidiabetogenic Effect of Glucagon-Like Peptide-1 (7-36) Amide in Normal Subjects and Patients with Diabetes Mellitus”,The New England Journal of Medicine, vol. 326(20) pp. 1316-1322, 1992.
Ghiglione, M. et al. “How glucagon-like is glucagons-like peptide-1?”,Diabetologia, vol. 27 pp. 599-600, 1984.
Schmidt, W.E. et al. “Glucagon-like peptide-1 but not glucagon-like peptide-2 stimulates insulin release from isolated rat pancreatic islets”,Diabetologia, vol. 28 pp. 704-707, 1985.
Drucker, D.J. “Glucagon and the Glucagon-like Peptides”,Pancreas, vol. 5(4) pp. 484-488, 1990.
Kojima, H., et al., “Combined Expression Of Pancreatic Duodenal Homeobox 1 And Islet Factor 1 Induces Immature Enterocytes To Produce Insulin”,Diabetes, vol. 51, No. 5, pp. 1398-1408, (2002).
Drucker, D.J., “Glucagon-Like Peptides: Regulators Of Cell Proliferation, Differentiation, And Apoptosis”,Molecular Endocrinology, vol. 17, No. 2, pp. 161-171, (2003).
Suzuki, A., et al., “Glucagon-Like Peptide 1 (1-37) Converts Intestinal Epithelial Cells Into Insulin-Producing Cells”,Proc. Natl. Acad. Sci. USA, vol. 100, No. 9, pp. 5034-5039, (2003).

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