Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1995-05-22
1999-03-23
Henley, III, Raymond
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
A61K 3140
Patent
active
058860231
ABSTRACT:
The present invention aims at providing a drug which is highly effective in improving decline of mental functions such as disorientation, which are the major symptoms of dementia such as Alzheimer type dementia or cerebrovascular dementia, as well as general side symptoms such as decreased spontaneity, contact disturbances, motivation, emotional disturbances, abnormal behaviors and disturbances in activity of daily living. The agent for improving dementia of the present invention comprises N-(2,6-dimethylphenyl)-2-(2-oxo-1-pyrrolidinyl)acetamide or a salt thereof as an active ingredient.
REFERENCES:
patent: 4341790 (1982-07-01), Betzing et al.
patent: 4385053 (1983-05-01), Reisberg
Oslo et al "Remington's Pharmaceutical Sciences" (1980) pp. 1554-1557.
Handbook of Pharmaceutical Excipients (1986) pp. 134-137.
Advances in Behavioral Biology, vol. 38B, 1990, pp. 367-370; H. Kojima et al.: "Effect of DM-9384, A New Pyrrolidone Derivative, on Passive Avoidance and Cerebral Choline Acetyltransferase Activity in Rats".
Advances in Behavioral Biology, vol. 38B, 1990, pp. 371-374; T. Kameyama et al.: "DM-9384, A Pyrrolidone Derivative, Ameliorates Basal Forebrain Lesion-induced Amnesia and Inhibits Cycloheximide-induced Decrease in the Number of GABA and Acetylcholine Receptors".
Advances in Alzhimer Disease Therapy Series, 1991, pp. 337-344, (editors R. Becker et al.), Birkhauser, Boston, Mass., US, M. Yoshida: "alzheimer Therapy with Cholinomimetics: Japanese Experience".
Pharmacology Biochemistry & Behavior, vol. 36, No. 2, 1990, pp. 233-236, Pergamon Press Plc, US; T. Nabeshima et al.: "Effects of DM-9382, a Pyrrolidone Derivative, on Alcohol-and Chlordiazepoxide-induced Amnesia in Mice".
Advances in Behavioral Biology, vol. 38A, 1990, pp. 735-738; C. Hara et al.: "Characteristics of Learning Deficit Induced by Ibotenic Acid Lesion of the Frontal Cortex Related with the Nucleus Basalis of Meynert in Rats" .
Hasegawa Kazuo
Honma Akira
Otomo Eiichi
Shiotani Tadashi
Takasu Yoshiyuki
Daiichi Pharmaceutical Co. Ltd.
Henley III Raymond
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