Agent for diminishing ascorbate interference in reagent systems

Details Agent for diminishing ascorbate interference in reagent systems Agent for diminishing ascorbate interference in reagent systems

1989-06-26

1990-09-04

Warden, Robert J.

Chemistry: analytical and immunological testing

Including sample preparation

Digestion or removing interfering materials

436 66, 436 95, 436904, G01N 100, G01N 3300, G01N 3372

Patent

active

049544519

ABSTRACT:
The present invention is directed to an agent and method for eliminating ascorbate interference in reagent systems, particularly assay systems using oxidase/peroxidase coupled reactions or similar type redox chemistry. The present invention can also be used in reagent systems involving enzyme/substrate reactions in which the substrate is sensitive to reductants such as ascorbate. The agents of this invention comprise water insoluble cerium (IV) compounds.

REFERENCES:
patent: 3411887 (1968-11-01), Ku
patent: 4288541 (1981-09-01), Magers
patent: 4310626 (1982-01-01), Burkhardt
patent: 4587220 (1986-05-01), Mayambala-Mwanika
patent: 4743559 (1988-05-01), Koever
patent: 4755472 (1988-07-01), Ismail
CRC Handbook of Physics and Chemistry, 46th ed., CRC Publishing: Cleveland, Ohio, 1965, p. B-165.

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