Drug – bio-affecting and body treating compositions – In vivo diagnosis or in vivo testing – Diagnostic or test agent produces in vivo fluorescence
Reexamination Certificate
2006-11-14
2006-11-14
Yu, Misook (Department: 1642)
Drug, bio-affecting and body treating compositions
In vivo diagnosis or in vivo testing
Diagnostic or test agent produces in vivo fluorescence
C514S538000
Reexamination Certificate
active
07135162
ABSTRACT:
A composition of a compound or derivative thereof in which at least one carbon atom of 5-aminolevulinic acid is a carbon isotope and/or a nitrogen atom in its amino group is a nitrogen isotope, and where said derivative is an ester, amide, salt, hydrate or solvate of the compound, and a diagnostically acceptable carrier. A method for detecting malignant tumors, by administering a tumor detecting effective amount to a host in need of tumor detection of a compound or derivative thereof in which at least one carbon atom of 5-aminolevulinic acid is a carbon isotope and/or a nitrogen atom in its amino group is a nitrogen isotope, and where said derivative is an ester, amide, salt, hydrate or solvate of said compound and detecting the malignant tumors using NMR.
REFERENCES:
patent: 6905671 (2005-06-01), Tanaka et al.
patent: 2-111747 (1990-04-01), None
patent: 4-9360 (1992-01-01), None
patent: 5-38294 (1993-02-01), None
patent: 97-03042 (1997-01-01), None
Z. Hua et al., Effectiveness of δ-Aminolevulinic Acid-induced Protoporphyrin as a Photosensitizer for Photodynamic Therapy in Vivo. Cancer Res., vol. 55, No. 8, p. 1723-31, Apr. 15, 1995.
J. Wang et al, An Efficient Synthesis of δ-Aminolevulinic Acid (ALA) and Its Isotopomers, Tetrahedron Letters, vol. 38, No. 5, p. 739-740, 1997.
International Search Report.
Jichlinski, et al., “Usefulness of fluorescence photodetection of neoplastic urothelial foci in bladder cancer following intravesical instillation of delta-aminolevulinic acid,” (1996), Pro. SPEI-int. Soc Opt. Eng. pp. 340-347.
Kennedy, et al., “Using delta-aminolevulinic acid in cancer therapy,” (1994), ACS Symp. Ser., pp. 291-302.
Jaffe, et al., “Nigrogen-15 and carbon-13 NMR studies of ligands bound to the 280,000-dalton protein porphobilinogen synthase elucidate the structores of enzyme-bound product and a Schiff base intermediate,” (1990), Biochemistry, pp. 8345-8350.
Sasaki Hiroshi
Tanaka Tohru
Cosmo Oil Co. Ltd.
Cosmo Research Institute
Sughrue & Mion, PLLC
Yu Misook
LandOfFree
Agent for diagnosing and treating malignant tumors does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Agent for diagnosing and treating malignant tumors, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Agent for diagnosing and treating malignant tumors will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3692638