Agent for desensitizing man and/or animals against an allergen

Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Liposomes

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Details

4241951, 424539, 424542, 424688, 514885, A61K 3722, A61K 3578, A61K 3558

Patent

active

050135554

ABSTRACT:
An agent for desensitization of man and/or animals against an allergen comprising liposomes that comprise the allergen is provided together with a method for inducing desensitization by administration of the agent.

REFERENCES:
patent: 4387091 (1983-06-01), Vijay et al.
patent: 4395394 (1983-07-01), Wolf et al.
Alving, C. R. et al, "Preparation and Use of Liposomes in Immunological Studies", in Liposome Technology, vol. II (1984), pp. 157-175.
Alving, C. R. et al., "Effectiveness of Liposomes as Potential Carriers of Vaccines: Applications to Cholera Toxin and Human Malaria Sporozoite Antigen", Vaccine, 4:166-172 (1986).
August, J. R., "The Reaction of Canine Skin to the Intradermal Injection of Allergenic Extracts," J. Am. An. Hosp. Assn., 18:157-163.
Ballou, W. R. et al., "Safety and Efficacy of a Recombinant DNA Plasmodium Falciparum Sporozoite Vaccine," The Lancet, i:1277-1281 (1987).
Edelman, R., "Vaccine Adjuvants," Rev. Infect. Dis., 2:370-383 (1980).
Gregoriadis, G. et al., "Entrapment of Proteins in Liposomes Prevents Allergic Reactions in Pre-Immunised Mice," FEBS Letters, 45:71-74 (1974).
Nesbitt, G. H. et al., "Aeroallergens," Compend. Cont. Educ. Prac. Vet., 6:63-68 (1984).
Nesbitt, G. H. et al., "Canine Atopy. Part I, Etiology and Diagnosis," Compend. Cont. Educ. Pract. Vet., 6:73-84 (1984).
Alving, C. R., "Liposomes as Carriers for Vaccines" in Liposomes, Ostro, M. J. (ed. 1987), pp. 195-218.
Richards, R. L. et al, "Liposomes as Carriers for a Malaria Peptide Vaccine: Developmental Aspects", in Immunopharmacology of Infectious Diseases: Vaccine Adjuvants and Modulators of Non-Specific Resistance, pp. 171-180 (1987).
Richards, R. L. et al., "Liposomes, Lipida, and Aluminum Hydroxide Enhance the Immune Response to a Synthetic Malaria Sporozoite Antigen," Infect. Immun., 56:682-686 (1988).
Lopez-Berestein, G. et al., "Liposomac Amphotericin B for the Treatment of Systemic Tunsac Infections in Patients".
Coune, A. et al., "IV Administration of a Water-Insoluble Antimitotic Compound Entrapped in Liposomes, Preliminary Report on Infusion of Large Volumes of Liposomes to Man," Cancer Tr. Rept., 67:1031-1033 (1983).
"With Cancer: A Preliminary Study," J. Infect. Dis., 151:704-710 (1985).

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