Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Reduced antigenicity – reduced ability to bind complement – or...
Patent
1981-03-13
1982-12-07
Phillips, Delbert R.
Drug, bio-affecting and body treating compositions
Immunoglobulin, antiserum, antibody, or antibody fragment,...
Reduced antigenicity, reduced ability to bind complement, or...
A61K 3700
Patent
active
043627188
DESCRIPTION:
BRIEF SUMMARY
TECHNICAL FIELD
The present invention relates to an agent for curing peripheral circulation insufficiency, more particularly to an agent for curing peripheral circulation insufficiency comprising .alpha..sub.1 -acid glycoprotein.
BACKGROUND ART
Blood of physiologically normal human beings or animals contains essentially 50% or more of the solid component comprising mainly blood corpuscles. Further, this component in the blood passes at a high speed through fine openings having an inside diameter of 3.mu. or so, such as fine blood vessels or capillaries, and the diameter of the blood corpuscles in this case is often larger than the inside diameter of the blood vessels. Accordingly, in such a case, the blood vessels must expand or the blood corpuscles themselves must change their shape so that the blood passes through the blood vessels without stagnation of the blood flow.
Thus the blood flow in peripheral blood vessels causes a trouble by hardening of the blood vessels, lowering of blood pressure or hyperfunction of fibrinolytic system, etc., due to old age to bring about diseases such as peripheral artery thrombosis, cerebral thrombosis, ischemic cardiopathy, thrombosis by acceleration of agglutination function, or peripheral circulation failure, etc.
Thus, for the purpose of curing and preventing such diseases, the present inventors have studied over a long period of time with respect to a method of preventing damage of cells when blood corpuscles, etc., in the blood pass through the blood vessels.
DISCLOSURE OF INVENTION
As a result, the present inventors have found that .alpha..sub.1 -acid glycoprotein useful for the process for producing a stabilized solution of protein which was previously filed by the present inventors (Unexamined patent publication Sho 53-37187) has a function that it inhibits coagulation or agglutination of the solid component in the blood such as red blood corpuscles, white blood corpuscles, marrow cells or other cells to alleviate or remove circulatory lesions caused thereby, and thus the present invention has been completed.
Namely, the present invention provides an agent for curing peripheral circulation insufficiency comprising .alpha..sub.1 -acid glycoprotein.
BRIEF DESCRIPTION OF DRAWINGS
FIG. 1 shows comparison between acceleration of fine opening passability of red blood corpuscles and hemolysis caused by .alpha..sub.1 -acid glycoprotein and those caused by human albumin, human .gamma.-globulin and dextran sulfate, and
FIG. 2 shows relation between a concentration of .alpha..sub.1 -acid glycoprotein and fine opening passability of red blood corpuscles.
BEST MODE FOR CARRYING OUT THE INVENTION
The .alpha..sub.1 -acid glycoprotein as an active ingredient of the present invention is the substance known already from Molecular Biology of Human Proteins, page 188 (1966) and Glycoproteins, edited by A. Gottschalk, pages 565-611 (1972), which is produced by the process described in, for example, Unexamined patent publication Sho 53-37187.
The curing function of .alpha..sub.1 -acid glycoprotein for peripheral circulation insufficiency, namely, increase in the fine opening passability of blood was tested and results obtained are as follows.
(1) Function exerting on the fine opening passability of red blood corpuscles.
EXPERIMENT 1
(1) One part by volume of human blood was mixed with 1 part by volume of a preservative solution (acid-citrate-dextrose solution) and preserved at 4.degree. C. Just before using, it was washed 4 times with about 8 times by volume of a saline solution (2,000 rotations/minute, for 3 minutes) and a 2% saline floating solution of red blood corpuscles was prepared.
(2) A solution prepared by dissolving .alpha..sub.1 -acid glycoprotein or a comparative substance shown in FIG. 1 in a saline solution was mixed with the same amount of the saline floating solution of red blood corpuscles, and the mixture was moderately shaked for 30 minutes at 37.degree. C. 1 ml of the mixture was taken out and filtered by means of a nitrocellulose membrane filter (p
REFERENCES:
Biol. Abstr., vol. 70, 76207.
Maeda Hiroshi
Nishi Katsuhide
Phillips Delbert R.
Yamanouchi Pharmaceutical Co. Ltd.
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