Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2002-11-07
2004-03-30
Weddington, Kevin E. (Department: 1614)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
Reexamination Certificate
active
06713500
ABSTRACT:
TECHNICAL FIELD
The present invention relates to an agent for controlling animal diseases caused by parasites, which contains, as an active ingredient, a specific imidazole compound. Such an agent for controlling animal diseases is useful, for example, as an agent for controlling parasites such as coccidia which are parasitic on animals.
BACKGROUND ART
Heretofore, various pest controlling agents or insecticides have been employed against parasites parasitic on animals such as domestic animals, domestic poultry or companion animals. For example, for controlling coccidia which are endobiotic protozoa belonging to genus Eimeria and which are widely distributed among various domestic animals and domestic poultry such as chickens, sulfa drugs; quinolines; anti-thiamine drugs; polyether antibiotics such as monensin, salinomycin and lasalocid; and nicarbazin as a synthetic agent, have widely been used.
Further, the specific imidazole compound which is used as an active ingredient of the agent for controlling animal diseases of the present invention, is a known compound disclosed in e.g. JP-A-1-131163, JP-A-63-255269, etc. However, it has not been known to use such compound as an agent for controlling animal diseases.
DISCLOSURE OF THE INVENTION
Usually, an animal disease caused by parasites will result from parasitism of the parasites on or in the body of a host animal. The parasites which cause an animal disease, are parasitic on the body surface, stomach, intestinal tract, lung, heart, liver, blood vessels, subcutis or lymphatic tissues of domestic animals, domestic poultry or companion animals, and are likely to bring about serious problems in many cases. Animal diseases caused by parasites are likely to bring about anemia, malnutrition, asthenia, weight loss, or disorder of intestinal tract walls or other tissues or organs, and if left untreated, hosts infested with the parasites are likely to die.
Further, coccidiosis which is one of animal diseases caused by parasites, presents a serious economical loss particularly to poultry industry. Further, this is one of diseases which are problematic in breeding not only poultry but also cattle, sheep, rabbits, dogs and cats. Therefore, control of coccidiosis will bring about a substantial benefit to the poultry industry, lively stock industry and breeding of companion animals. On the basis of such a concept, the present invention provides an agent for controlling animal diseases caused by parasites.
The present inventors have conducted an extensive research for compounds which are capable of controlling animal diseases, particularly coccidiosis, caused by parasites. As a result, they have found that a certain specific imidazole compound which is known to have an agricultural application, has an effect for controlling animal diseases caused by parasites, and the present invention has been accomplished on the basis of this discovery.
Namely, the present invention provides an agent for controlling animal diseases caused by parasites, which contains, as an active ingredient, an imidazole compound represented by the formula (I):
wherein R
1
is a cyano group, a
group or a
group {wherein each of R
5
and R
6
is a hydrogen atom, an alkyl group which may be substituted, an alkenyl group which may be substituted, an alkynyl group which may be substituted, a cycloalkyl group which may be substituted, an aryl group which may be substituted, or a —CO—R
7
group (wherein R
7
is an alkyl group which may be substituted, an alkoxy group which may be substituted, or an aryl group which may be substituted)},
each of R
2
and R
3
is a hydrogen atom; a halogen atom; a hydroxyl group; a nitro group; a cyano group; a thiocyanate group; a trimethylsilyl group; an alkyl group which may be substituted; a cycloalkyl group which may be substituted; an alkenyl group which may be substituted; a cycloalkenyl group which may be substituted; an alkynyl group which may be substituted; an alkoxy group which may be substituted; a cycloalkyloxy group which may be substituted; an alkenyloxy group which may be substituted; a cycloalkenyloxy group which may be substituted; an alkynyloxy group which may be substituted; an aryl group which may be substituted; an aryloxy group which may be substituted; a 5- or 6-membered aromatic heterocyclic group which may be substituted; a —SO
n
R
8
group {wherein R
8
is an alkyl group which may be substituted; a cycloalkyl group which may be substituted; an alkenyl group which may be substituted; a cycloalkenyl group which may be substituted; an alkynyl group which may be substituted; an aryl group which may be substituted; a pyridyl group which may be substituted, or a —N(R
9
)R
10
group (wherein each of R
9
and R
10
is an alkyl group), and n is an integer of from 0 to 2}; or a
group (wherein W
1
is an oxygen atom or a sulfur atom, W
2
is an oxygen atom, a sulfur atom or —NH—, m is an integer of from 0 to 1, and R
11
is an alkyl group which may be substituted; or an aryl group which may be substituted),
R
4
is an alkyl group which may be substituted; a cycloalkyl group which may be substituted; an aryl group which may be substituted; a thienyl group which may be substituted; a furyl group which may be substituted; or a —N(R
12
)R
13
group (wherein each of R
12
and R
13
is a hydrogen atom; an alkyl group which may be substituted; or an alkenyl group which may be substituted, or they form, together with the adjacent nitrogen atom, a 5- to 7-membered saturated heterocyclic group, provided that a case where R
12
and R
13
are simultaneously hydrogen atoms, is excluded),
provided that a case where R
2
and R
3
are simultaneously hydrogen atoms, is excluded.
In the formula (I), the alkyl moiety contained in R
2
to R
13
may be one having a carbon number of from 1 to 12, and it may, for example, be a methyl group, an ethyl group, a n-propyl group, an isopropyl group, a n-butyl group, a sec-butyl group, an isobutyl group, a tert-butyl group, a n-pentyl group, a n-hexyl group, a heptyl group, an octyl group, a nonyl group or a decyl group. The cycloalkyl group represented by R
2
, R
3
, R
4
, R
5
, R
6
and R
8
, may be one having a carbon number of from 3 to 7, and it may, for example, be a cyclopropyl group, a cyclobutyl group, a cyclopentyl group or a cyclohexyl group. The alkenyl group contained in R
2
, R
3
, R
8
, R
12
and R
13
, may be one having a carbon number of from 2 to 12, and it may, for example, be an allyl group or a geranyl group. The cycloalkenyl group represented by R
2
, R
3
and R
8
may be one having a carbon number of from 5 to 8, and it may, for example, be a cyclopentenyl group, a cyclohexenyl group or a cyclooctenyl group. The alkynyl group contained in R
2
, R
3
and R
8
may be one having a carbon number of from 2 to 12, and it may, for example, be a 2-propynyl group.
The aryl group which may be substituted, represented by R
2
, R
3
, R
4
, R
5
, R
6
, R
7
, R
8
and R
11
, or the aryl moiety of the aryloxy group which may be substituted, represented by R
2
and R
3
, may, for example, be a phenyl group or a naphthyl group. The aryl group for R
2
, R
3
and R
8
is preferably a phenyl group or a naphthyl group. The aryl group for R
4
, R
5
, R
6
, R
7
and R
11
is preferably a phenyl group. The aryloxy group which may be substituted, represented by R
2
and R
3
, is preferably a phenoxy group. The 5- or 6-membered aromatic heterocyclic group which may be substituted, represented by R
2
and R
3
, may be one containing at least one hetero atom selected from the group consisting of an oxygen atom, a sulfur atom and a nitrogen atom, in its ring, and it may, for example, be a thienyl group which may be substituted, a furyl group which may be substituted, a thiazolyl group which may be substituted, or a pyridyl group which may be substituted.
The substituent for the alkyl group which may be substituted, represented by R
2
, R
3
, R
4
, R
5
, R
6
, R
7
, R
8
, R
11
, R
12
and R
13
; the cycloalkyl group which may be substituted, represented by R
2
, R
3
, R
4
, R
5
, R
6
and R
8
;
Morino Kyuya
Ogawa Munekazu
Yotsuya Shuichi
Ishihara Sangyo Kaisha Ltd.
Weddington Kevin E.
LandOfFree
Agent for controlling animal diseases caused by parasites does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Agent for controlling animal diseases caused by parasites, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Agent for controlling animal diseases caused by parasites will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3292275