Agent and product for the diagnosis and treatment of tumors and

Details Agent and product for the diagnosis and treatment of tumors and Agent and product for the diagnosis and treatment of tumors and

1990-02-26

1991-06-04

Maples, John S.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

424 9, 424450, 435832, 435872, 435879, A61K 4902, A61K 3722, C12N 100, C12N 120

Patent

active

050212346

ABSTRACT:
An agent for the diagnosis and treatment of malignant tumors and for the treatment of lowered cellular and humoral immune defense is described which contains an immune modulator, a lipopolysaccharide or an immune modulator tagged with a radioactive tracer, a dyestuff or a cytostatic, or a similar polysaccharide, possibly in and/or on liposomes or lipidized. There is also described a product which contains the agent together with an adjuvant consisting of an aldehyde and an alcohol. There is also described a method for the diagnosis of malignant tumors comprising the step of administering to a mammal a diagnostic effective amount of the agent, optionally together with an adjuvant consisting of an aldehyde and an alcohol.

REFERENCES:
patent: 4029762 (1977-06-01), Galanos et al.
Osborn et al., "Incorporation of Lipid Vesicles by Salmonella", Ann., N.Y.; Acad. Sci., 308, pp. 215-225, 1978.
Chemical Abstracts, Band 98, Nr. 25, 20, Jun. 1983; p. 425, "The activation of tumoricidal properties in macrophages of endotoxin responder etc." & J. Reticuloendothel. Soc. 1983; 33(3), 165-174.
The Journal of Immunology, Band 130, Nr. 4, Apr. 1983; pp. 1500-1502, "The activation of human monocytes by liposome-encapsulated muramyl etc.".
Biological Abstracts, Band 6; Nr. 7; 1983, "In vitro effects of lipopolysaccharides and mycobacterial etc." & Res. Vet. Sci. 34(2); pp. 212-217, 1983.
Biological Abstracts, Band 62, Nr. 6; 1975; "Cell walls of mycrobacteria and related organisms: Chemistry and etc." & Mol Cell. Biochem. 7(2), pp. 87-104, 1975.
Chemical Abstracts, Band 91, Nr. 23, Dec. 3, 1979; p. 57, "Evaluation of the immunomodulator administration etc." & Gan To Kagaku Ryoho 1979; 6(Rinji Zokan 2), 219-230.
Inspection and Immunity, Feb. 1975; pp. 257-264, "Isolation of Mitogenic and Adjuvant Active Fractions etc." by Rita Ciorbaru et al.

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