Age formation inhibitors

Details Age formation inhibitors Age formation inhibitors

1993-06-02

1994-04-12

Gerstl, Robert

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514342, 546280, 548196, C07D27748, A61K 31425

Patent

active

053026080

ABSTRACT:
Thiourea compounds represented by the general formula: ##STR1## wherein A is an aromatic ring group which may be substituted; R.sup.1 is a hydrogen atom or a lower alkyl or aryl group which may be substituted, or may combine with A to form a cyclic ring; and --COB is an acyl group of a carboxylic acid or an esterified carboxyl group or salts thereof are provided as agents for inhibiting the formation of AGE (Advanced Glycosidation End Product), which are employable for treating diseases caused by AGE-formation, such as diabetic complications, senile cataract, atherosclerosis etc.

REFERENCES:
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M. Nagano et al., "Organic Sulfur Compounds, XI. Synthesis of 2-alkylthiothiazolo[3.2-alpha]-2-triazine-4-ones", Chemical Abstracts, vol. 78, No. 18, May 7, 1973, pp. 474-475, abs. no. 12448m.
Sumiuki Akihama et al., "Antiviral activity of Thiazole-thiourea Derivatives", Chemical Abstracts, vol. 67, No. 23, Dec. 4, 1967, p. 9986, abstract no. 106086f, Columbus, Ohio.
G. Ramachandraiah et al., "Synthesis of 2-Aroylimino-5-Arylthiazolo[3,2-b]-1,2,4-thiadiazolines", Sulfur Lett., vol. 6, No. 1, pp. 1-6 (1987). (Abstract only).
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