AGE-1 polypeptides and related molecules and methods

Details AGE-1 polypeptides and related molecules and methods AGE-1 polypeptides and related molecules and methods

2006-08-22

2006-08-22

Paras, Jr., Peter (Department: 1632)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C435S194000, C435S320100, C435S325000, C435S006120, C435S007100, C435S070100

Reexamination Certificate

active

07094889

ABSTRACT:
Disclosed are substantially pure AGE-1 polypeptides and purified DNAs, vectors, and cells encoding those polypeptides. Also disclosed are methods for determining longevity and isolating antagonists using the AGE-1 sequence.

REFERENCES:
patent: US97/13914 (1997-09-01), None
Genbank accession No. Q04441. JO2096597A , 1990.
Leung TK et al. 1990. Genbank accession No. p. 17066.
Miyazaki K et al. 1992. Genbank accession No. p. 33197.
Clements JE et al. Clinical Microbiology Reviews 9:100-117, 1996.
Hiles et al 1992. Genbank accession No. A43322.
Goode et al 1994. Genbank accession No. R46294.
Wilson et al 1994. Genbank accession No. Z66519.
J Rudinger, Peptide Hormones, “Characteristics of the amino acids as components of a peptide hormone sequence,” Jun. 1976, pp. 1-7.
Friedman et al., “A Mutation in the age-1 Gene inCaenorhabditis elegansLengthens Life and Reduces Hermaphrodite Fertility”,Genetics, 118: 75-86, (1988).
Hodes et al., “Longevity Assurance Genes: How Do They Influence Aging and Life Span?”,JAGS, 44: 988-991, (1996).
Johnson et al., “Comparing mutants, selective breeding, and transgenics in the dissection of aging processes ofCaenorhabditis elegans”, Genetica, 91: 65-77, (1993).
Lithgow et al., “Molecular genetics ofCaenorhabditis eleganslife span”,Journal of Cell. Biochem. Suppl., 17:144, (1993).
Murakami et al., “A Genetic Pathway Conferring Life Extension and Resistance to UV Stress inCaenorhabditis elegans”, Genetics, 143: 1207-1218, (1996).
Hu et al., “Cloning of a novel ubiquitously expressed human phosphatidylinositol”,Database Online, Accession No. P42338,(1995).
Swinburne, “TheC. elegansSequencing Consortium”,Database Online, Accession No. Z66519, (1995).
Whitman et al., “Type I phosphatidylinositol kinase makes a novel inositol phospholipid, phosphatidylinositol-3-phosphate”,Nature, 332: 644-646, (1988).
Bernard, V. et al..,Experientia, vol. 52, p. A37, abstract S10-47, TheC. elegansphosphatidylinositol 3-kinase (VPS34).
Tedesco, P.M. et al., ‘Cloning a gene for life-extension inCaenorhabditis elegans,’ abstract, UCLA Symposium on Molecular and Cellular Biology, New Series, 1990, vol. 123, pp. 3-17, database CAPLUS on STN, Institute of Behavioral Genetics, (Boulder, Colorado, USA).
Morris, J.Z. et al.,Nature, Aug. 1996, vol. 382, pp. 536-539, A phosphtidylinositol-3-OH kinase family member regulating longevity and diapause inCaenorhabditis elegans.
Malone, E.A. et al.,Genetics, Jul. 1996, vol. 143, No. 3, pp. 1193-1205, Genetic analysis of the roles of daf-28 and age-1 in regulatingCaenorhabditis elegansdauer formation.
Alberts et al., Molecular Biology of the Cell, Second Edition. New York: Garland Publishing, Inc., pp. 258-266, 1989.
Dorman, J.B. et al.,Genetic, 141(4), 1399-1406 (1995).
Gottlieb, S. et al.,Genetics, 137, pp. 107-120 (1994), daf-2, daf-16 and daf -23: Genetically Interacting Genes Controlling Dauer Formation InCaenorhabditis elegans.
Jazwinski, s. Michal,Science, vol. 273, pp. 54-59 (1996), Longevity, Genes, and Aging.
Kenyon, C. et al.,Nature, 366, pp. 461-464 (1993).
Kenyon, C.,Cell, 1996, 84(4): pp. 501-504 (1996).
Kimura, K.D. et al.,Science, 277(5328): pp. 942-946 (1997).
Larsen, P.L. et al.,Genetics, 139, pp. 1567-1583 (1995).
Larsen, P.,Proc. Natl. Acad. Sci., 90, pp. 8905-8909 (1993).
Lin, K. et al.,Science, 278(5341): pp. 1319-1322 (1997).
Ogg, S. et al.,Nature, 389(6654): pp. 994-999 (1997).
Okada, T. et al.,J. Biol. Chem., 269, pp. 3563-3567 (1994).
Thelen, M. et al.,Proc. Natl. Acad., Sci. 91, pp. 4950-4964 (1994).
VanFleteren, J.R.,J. Biochem., 292, pp. 605-608 (1993.
Vowels, J.J. et al.,Genetics, 130, pp. 105-123 (1992).

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