AFM for simultaneous recognition of multiple factors

Chemistry: molecular biology and microbiology – Apparatus – Including measuring or testing

Reexamination Certificate

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Details

C435S007100, C435S283100, C435S287100, C436S518000, C436S524000, C422S050000, C422S068100, C850S005000, C850S033000

Reexamination Certificate

active

07745206

ABSTRACT:
An atomic force microscope and a method for detecting interactions between a probe and two or more sensed agents on a scanned surface and determining the relative location of two or more sensed agents is provided. The microscope has a scanning probe with a tip that is sensitive to two or more sensed agents on said scanned surface; two or more sensing agents tethered to the tip of the probe; and a device for recording the displacement of said probe tip as a function of time, topographic images, and the spatial location of interactions between said probe and the two or more sensed agents on said surface.

REFERENCES:
patent: 5958701 (1999-09-01), Green et al.
patent: 6189374 (2001-02-01), Adderton et al.
patent: 2004/0129064 (2004-07-01), Hinterdorfer et al.
patent: 2007/0128623 (2007-06-01), Park et al.

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