Liquid purification or separation – With means to add treating material – Chromatography
Patent
1988-11-09
1993-08-31
Therkorn, Ernest G.
Liquid purification or separation
With means to add treating material
Chromatography
210635, 210656, 21050034, 21050041, 2105021, 264 48, 427221, 427222, 427245, 502402, 604 6, B01D 1508
Patent
active
052406016
ABSTRACT:
A method of coating chromatographic particulate supports to provide a biocompatible outer layer of synthetic membrane-type film which prevents the release of fines but permits the adsorption of components to an affinity ligand is described. The matrix is provided with a membrane-type coating, which prevents leaching of fines, with a pore size of at least 20 angstroms. The coating is applied to a solid particulate under conditions where an integral membrane coat will be formed. It may also be necessary to control the size and number of pores of the membranes by treating a suspension of the solid support in a solvent which contains 0.1-1% of the support weight of a biocompatible polymer along with 0.5-5% of the weight of said polymer of a dissolved compatible pore-controlling component. The solvent is then removed from the suspension and the membrane-coated material used in extracorporeal treatment of body fluids or in other chromatographic techniques. The coating process can be conducted before or after the particulate support is functionalized and/or derivatized.
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Chembiomed Ltd.
Therkorn Ernest G.
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