Affinity supports for hemoperfusion

Details Affinity supports for hemoperfusion Affinity supports for hemoperfusion

1991-04-03

1992-09-22

Therkorn, Ernest G.

Liquid purification or separation

With means to add treating material

Chromatography

2105021, 210635, 210656, 502402, 502404, B01D 1508

Patent

active

051494256

ABSTRACT:
A method of coating chromatographic particulate supports to provide a biocompatible outer layer of synthetic membrane-type film which prevents the release of fines but permits the adsorption of components to an affinity ligand is described. The matrix is provided with a membrane-type coating, which prevents leaching of fines, with a pore size of at least 20 angstroms. The coating is applied to a solid particulate under conditions where an integral membrane coat will be formed. It may also be necessary to control the size and number of pores of the membranes by treating a suspension of the solid support in a solvent which contains 0.1-1% of the support weight of a biocompatible polymer along with 0.5-5% of the weight of said polymer of a dissolved compatible pore-controlling component. The solvent is then removed from the suspension and the membrane-coated material used in extracorporeal treatment of body fluids or in other chromatographic techniques. The coating process can be conducted before or after the particulate support is functionalized and/or derivatized.

REFERENCES:
patent: 3577226 (1972-05-01), Elbert
patent: 3725113 (1973-04-01), Chang
patent: 3795313 (1974-03-01), Kirkland et al.
patent: 3808125 (1974-04-01), Good
patent: 3878092 (1975-04-01), Fuller
patent: 3953360 (1976-04-01), Morishita et al.
patent: 3954678 (1976-05-01), Maquisee
patent: 3983053 (1976-09-01), Courtney et al.
patent: 3983299 (1976-09-01), Regnier
patent: 4029583 (1977-06-01), Ho Chang et al.
patent: 4051300 (1977-09-01), Klein et al.
patent: 4070348 (1978-01-01), Kraemer
patent: 4076892 (1978-02-01), Fennimore et al.
patent: 4104209 (1978-08-01), Mikes et al.
patent: 4137401 (1979-01-01), Lemieux et al.
patent: 4140652 (1979-02-01), Korshak et al.
patent: 4140653 (1979-02-01), Imura et al.
patent: 4163725 (1979-08-01), Sano et al.
patent: 4171283 (1979-10-01), Nakashima
patent: 4177038 (1979-12-01), Biebricher et al.
patent: 4238473 (1980-12-01), Lemieux et al.
patent: 4248736 (1981-02-01), Fuchigami et al.
patent: 4250256 (1981-02-01), Wielinger et al.
patent: 4332694 (1982-06-01), Kalal et al.
patent: 4352884 (1982-10-01), Nakashima
patent: 4362620 (1982-12-01), Lemieux et al.
patent: 4486376 (1984-12-01), Makino et al.
patent: 4557925 (1985-12-01), Lindahl et al.
patent: 4627992 (1986-12-01), Badenhop et al.
patent: 4629619 (1986-12-01), Lindahl et al.
patent: 4629620 (1986-12-01), Lindahl et al.
patent: 4634604 (1987-01-01), Tlustakova et al.
patent: 4663163 (1987-05-01), Hou et al.
patent: 4673734 (1987-06-01), Tayo et al.
patent: 4681870 (1987-07-01), Balint, Jr. et al.
patent: 4724207 (1988-02-01), Hou et al.
patent: 4761232 (1988-08-01), Bright
patent: 4772391 (1988-09-01), Baker et al.
patent: 4781838 (1988-11-01), Crassous et al.
patent: 4824678 (1989-04-01), Lindahl et al.
Refojo, J. Ap. Poly. Sci. (1965) 9:3417.intg.3125.
White, J. Phys. Chem. (1960) 64:1563-1565.
Schenkein et al., J. Clin. Invest. (1971) 50:1864-1868.
Lyle et al., J. Immunol. (1974) 113:517-521.
Terman et al., Clin. Exp. Immunol. (1977) 28:180-188.
Terman et al., New Eng. J. Med. (1981) 305:1195-1200.
Besa et al., Amer. J. Med. (1981) 71:1035-1040.
Messaikeh et al., Biological and Biomechanical Performance of Biomaterials (1986) Christel et al., Eds., Elsevier, Amsterdam pp. 321-326.
Margel et al., Ap. Biochem. Biotechnol. (1986) 12:37-66.
Bensinger et al., Transfusion (1981) 21:335-342.
Bensinger et al., New Eng. J. Med. (1981) 304:160-162.
Bensinger et al., J. Clin. Apheresis (1982) 1:2-5.
Bensinger et al., Vox Sang (1985) 48:357-361.
Chang, Trans. Amer. Soc. Artif. Int. Organs (1980) 26:546-549.
Osterwalder et al., Blut (1986) 53:379-390.
Bussel et al., Plasma Ther. Trans. Technol. (1985) 6:461-464.
Raja et al., Trans. Amer. Soc. Artif. Internal Organs (1986) 32:102-103.
Bannett et al., Transplantation (1987) 43:909-910.
Hasirci et al., J. Biomed. Materials Res. (1986) 20:963-970.
Neumann et al., "Biocompatible Polymers, Metals, and Composites" (1983) Szycher, editor; Technomic, PA pp. 53-80.
Thomas et al., "Biological and Biomechanical Performance of Biomaterials" (1986) Christel et al., eds. Elsevier, Amsterdam pp. 379-383.
Zingg et al., Biomaterials (1981) 2:156-158.
Strong et al., Anal. Biomed. Eng. (1982) 10:71-82.
Boardman, J. Chromatog. (1959) 2:388-397.

Affiliated with

Also associated with

Rating

Affinity supports for hemoperfusion does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Affinity supports for hemoperfusion, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Affinity supports for hemoperfusion will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1066211