Affinity small molecules for the EPO receptor

Details Affinity small molecules for the EPO receptor Affinity small molecules for the EPO receptor

2006-05-02

2006-05-02

Tate, Christopher R. (Department: 1654)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

C514S002600, C530S300000

Reexamination Certificate

active

07037902

ABSTRACT:
Compounds are provided that complex with the modulating domain of erythropoietin receptor (EPO-R) for use with EPO-R to determine the presence of EPO-R, the ability of other molecules to bind to the modulating domain in competitive assays and to induce a signal by EPO-R into a cell when bound by the subject compounds in a physiological environment. The compounds are characterized by having a six-membered heterocyclic ring comprising at least one nitrogen atom and include substituted triazolopyrimidine, pyridazinone, pyridine and piperidine.

REFERENCES:
patent: 4546104 (1985-10-01), Campbell et al.
patent: 5942520 (1999-08-01), Pamukcu et al.
SA Qureshi, et al. PNAS (1999) 96, 12156-12161.
DL Boger and J Goldberg. Bioorg. Med. Chem. (2001) 9, 557-562.
DM Wojchowski, et al. Exp. Cell Res. (1999) 253, 143-156).
PA Tilbrook and SP Klinken Intl. J. Biochem. Cell Biol. (1999) 31, 1001-1005.

Affiliated with

Also associated with

Rating

Affinity small molecules for the EPO receptor does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Affinity small molecules for the EPO receptor, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Affinity small molecules for the EPO receptor will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3651220