Affinity selection of ligands by mass spectroscopy

Details Affinity selection of ligands by mass spectroscopy Affinity selection of ligands by mass spectroscopy

1995-01-19

1999-04-06

Hutzell, Paula K.

Chemistry: analytical and immunological testing

Involving immune complex formed in liquid phase

Separation of immune complex from unbound antigen or antibody

436528, 436532, 436533, 436534, 436518, G01N 33537

Patent

active

058917420

ABSTRACT:
Compounds are quickly selected from a combinatorial library by contacting the library with a target (e.g., receptor), separating non-binding compounds from compound-target complexes, and analyzing the complexes or eluted compound by mass spectroscopy. SAR information is obtained by performing this selection at two or more different ratios of compound to target.

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Lebl et al Biopolymers 1995 37(3) 177-98 Abstract only.

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