Affinity purified heparin

Details Affinity purified heparin Affinity purified heparin

1991-04-29

1998-09-15

Davenport, Avis M.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

8 to 10 amino acid residues in defined sequence

530412, 536 21, A61K 3800, C07K 500, C07K 700

Patent

active

058079823

ABSTRACT:
The present invention relates to a method for purifying heparin into two subspecies of molecules, one which binds transforming growth factor-.beta. (TGF-.beta.), and another which does not. The method involves using a peptide, immobilized on a chromatography substrate, that is homologous to the heparin-binding region of TGF-.beta. and allowing the heparin to contact the immobilized peptide for a sufficient time to cause binding. The fraction of heparin which does not bind to the peptide retains its activity as an anticoagulant but is devoid of the ability to bind TGF-.beta..

REFERENCES:
patent: 4971952 (1990-11-01), Bentz et al.
Cheifetz et al., Cell, vol. 48, pp. 409-417, Feb. 13, 1987.
Andersson et al., Biological Abstracts, BA:3733, p. 357, Jan. 1, 1978.
Jozefonnicz et al., Chemical Abstracts, CA113(21): 187597s, 1990.

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