Affinity membranes having pendant hydroxy groups and processes f

Details Affinity membranes having pendant hydroxy groups and processes f Affinity membranes having pendant hydroxy groups and processes f

1988-01-14

1990-04-24

Sever, Frank

Liquid purification or separation

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Material

21050041, 562544, B01D 1300

Patent

active

049198114

ABSTRACT:
Polymeric affinity membranes comprise a precursor filtration membrane and a plurality of reaction sites provided on the surface of the membrane selective to binding a specific biological material. A process for the preparation of such affinity membranes includes the steps of providing a copolymer compatible with a water insoluble polymer matrix and having a plurality of hydroxyl groups, activating the hydroxyl groups and a compound selected from the group consisting of organic compounds reactive with a hydroxyl group in the presence of water miscible solvent to provide a derivatized copolymer containing active adducts, forming a solution of the derivatized copolymer and the polymer matrix to form a polymer blend solution, casting the polymer blend solution and, quenching the cast polymer blend solution in water. A process for selectively removing biological materials from fluids includes the step of passing the fluids over an affinity membrane which comprises a precursor filtration membrane and a plurality of reaction sites provided on the surface of the membrane selective to binding a specific biological material.

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patent: 4754089 (1988-06-01), Matson et al.
"Affinity Binding, an Evolving Technology", The 1986 Fourth Annual Membrane Technology/Planning Conference, Nov. 5-7, 1986, Randall H. Morse.

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