Affinity membrane system and method of using same

Details Affinity membrane system and method of using same Affinity membrane system and method of using same

1997-07-11

1999-02-16

Kim, John

Liquid purification or separation

Processes

Liquid/liquid solvent or colloidal extraction or diffusing...

2103216, 21032179, 2103218, 21032188, 21032189, 21050023, 210650, 210651, 435181, 604 4, B01D 6302, B01D 6100, A61M 134

Patent

active

058716491

ABSTRACT:
The present invention provides an improved affinity membrane device and method for the effective removal of target molecules in plasma. The affinity membrane device is designed for use in an extracorporeal blood circuit and can be employed concurrently with other therapeutic processes for the purification of blood. The device of the present invention consists of hollow fiber membranes having specified dimensions and transfer properties, ligand immobilized to the pore surface of the hollow fibers, and a housing to encase the hollow fibers and allow appropriate entry and exit of the blood. In a preferred embodiment, specific immobilization chemistries are utilized to attach the ligands to the hollow fibers for optimal function.

REFERENCES:
patent: 4163714 (1979-08-01), Gregor
patent: 5286449 (1994-02-01), Kuroda et al.
patent: 5310688 (1994-05-01), Zale et al.
patent: 5418061 (1995-05-01), Parham et al.
patent: 5683916 (1997-11-01), Goffe et al.
(C) WPI/Derwent; Kuraray Co. Ltd., Treatment of Liquied For Analytical Or Medical Use Using Porous Holloiw Fibre Through Which Immobilised Physiologically Active Substance Permeates, 9 pp; 8 May 1986.

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