Affinity chromatography sorbent

Details Affinity chromatography sorbent Affinity chromatography sorbent

1987-02-04

1988-10-18

Kight, John

Synthetic resins or natural rubbers -- part of the class 520 ser

Synthetic resins

Mixing of two or more solid polymers; mixing of solid...

530413, 530417, 530810, 530811, 530812, 530813, 530814, 530815, 210692, 536 185, A23J 100, C07G 700, C08L 8900

Patent

active

047788461

ABSTRACT:
A novel process for the isolation and purification of vancomycin class antibiotics which utilized affinity chromatography by the formation of a sorption complex between the antibiotic and an immobilizing ligand selected from -D-alanyl-D-alanine or -X-D-alanyl-D-alanine, wherein X is an amino acid radical and the novel affinity chromatography sorbent employed therein are disclosed.

REFERENCES:
patent: 3969284 (1976-07-01), Gray
patent: 4171412 (1979-10-01), Coupek et al.
patent: 4411832 (1983-10-01), Cuatrecasas et al.
Bio-Rad Laboratories Technical Bulletin 1085 "Activated Affinity Supports: Affi-Gel .RTM. 10 and 15" 1982.
Cuatrecasas, "Journal of Biological Chemistry", vol. 245, No. 12, pp. 3059-3065, 1970.
DePedro et al., "FEMS Microbiology Letters", 9(1980), pp. 215-217.
Cuatrecasas, "Biochemistry", vol. 11, No. 12, pp. 2291-2298, 1972.
Perkins et al. "Annals of the New York Academy of Sciences", vol. 235, pp. 348-363, 1974.
Bio-Rad Bulletin 1085, 1982.
Williams et al., "Topics in Antibiotic Chemistry", 5 pp. 119-158; 1980.
Nieto et al., Biochemical Journal, 123, pp. 789-803, 1971.

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