Chemistry of carbon compounds – Miscellaneous organic carbon compounds
Patent
1976-08-10
1978-11-14
Woodberry, Edward M.
Chemistry of carbon compounds
Miscellaneous organic carbon compounds
210 31C, 260112R, 536 4, 424 12, 424 92, C08L 102, C08L 302, C08L 502
Patent
active
041254929
ABSTRACT:
Columns of polysaccharide, e.g., agarose, derivatives comprising covalently bonded gangliosides quantitatively adsorb the .sup.125 I-labeled cholera toxin of chromatographed samples. The most preferred derivatives are those wherein the gangliosides are coupled to "macromolecules" [native albumin, denatured albumin, poly(L-lysine) and poly(L-lysyl-DL-alanine) graft copolymers] which themselves are covalently bonded to the, e.g., agarose. The soluble ganglioside polymers can prevent the binding of .sup.125 I-labeled toxin to liver membranes as well as block completely the lipolytic activity of cholera toxin on fat cells, and thus are useful in the management of the manifestations of clinical cholera.
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Cuatrecasas Pedro
Parikh Indu
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