Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Hydrolase
Patent
1991-08-16
1994-01-11
Cashion, Jr., Merrell C.
Chemistry: molecular biology and microbiology
Enzyme , proenzyme; compositions thereof; process for...
Hydrolase
435195, 435814, 435815, 530412, 530413, C12N 948, A23J 100
Patent
active
052780619
ABSTRACT:
Affinity chromatography matrices are disclosed which are useful in purifying interleukin-1.beta. converting enzyme (ICE) from crude or partially purified cell lysate preparations. The chromatographic matrices comprise a specific ICE inhibitor of Formula I which is attached to an affinity column support by means of a bifunctional spacer. ##STR1##
REFERENCES:
Sleath et al. J. Biol. Chem. vol. 265 No. 24 (Aug. 1990) 14526-14528.
Bull et al. J. Biol. Chem. vol. 260 No. 5 (Mar. 1985) pp. 2963-2972.
Black, et al J. Biol. Chem. 263, 9437-9442 (1988).
Black, et al J. Biol. Chem. 264, 5323-5326 (1989).
Black, et al FEB Lett. 247, 286-290 (1989).
Kostura, et al Proc. Natl. Acad. Sci. 86, 5227-5231 (1989).
Bull Herb G.
Chapman Kevin T.
Cashion Jr. Merrell C.
Celsa Bennett
DiPrima Joseph F.
Merck & Co. , Inc.
Panzer Curtis C.
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