Affinity bound collagen matrices for the delivery of biologicall

Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Matrices

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514777, 514801, A61K 4736, A61K 9742

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active

056933410

ABSTRACT:
Affinity bound collagen matrices for the delivery of biologically active agents, and methods for preparing such matrices, are disclosed. A preferred method for preparing the matrices of the invention comprises mixing a binding ligand and an active agent together, allowing the resulting binding ligand-active agent mixture to form an affinity bound complex, then combining the resulting affinity bound complex with collagen to form a matrix. Particular affinity bound matrices comprising collagen, heparin, and an active agent are also disclosed, as well as methods for using the matrices of the invention for delivery of biologically active agents.

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