Affinity adsorbents for plasminogen

Details Affinity adsorbents for plasminogen Affinity adsorbents for plasminogen

2011-08-16

2011-08-16

Tsang, Cecilia (Department: 1654)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

C536S028300, C530S413000, C424S145100

Reexamination Certificate

active

07998960

ABSTRACT:
For the separation, removal, isolation, purification, characterization, identification or quantification of plasminogen or a protein that is a plasminogen analogue, an affinity adsorbent is used that is a compound of formula (II) wherein one X is N and the other is N, C—Cl or C—CN; A is a support matrix, optionally linked to the triazine ring by a spacer; Z is O, S or N—R and R is H, C1-6alkyl, C1-6hydroxyalkyl, benzyl or &bgr;-phenylethyl; B is an optionally substituted hydrocarbon linkage containing from 1 to 10 carbon atoms; D is H, OH or a primary amino, secondary amino, tertiary amino, quaternary ammonium, imidazole, guanidino or amidino group; or B-D is —CHCOOH—(CH2)3-4—NH2; and q is 2 to 6.

REFERENCES:
patent: 2002/0192794 (2002-12-01), Dadd et al.
patent: WO 00/67900 (2000-11-01), None
patent: WO-00/67900 (2000-11-01), None
patent: WO 00/67900 (2000-11-01), None
Lowe, Christopher R. (2001) “Combinatorial approaches to affinity chromatography”Current Opinion in Chemical Biology5:248-256.

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