Affinity adsorbents for Factor VIII and von Willebrand's Factor

Details Affinity adsorbents for Factor VIII and von Willebrand's Factor Affinity adsorbents for Factor VIII and von Willebrand's Factor

2011-06-14

2011-06-14

Gakh, Yelena G (Department: 1777)

Chemistry: analytical and immunological testing

Including sample preparation

Liberation or purification of sample or separation of...

C436S177000, C436S161000, C436S086000, C436S063000, C544S180000, C544S194000, C544S204000, C544S212000

Reexamination Certificate

active

07960182

ABSTRACT:
For the separation, removal, isolation, purification, characterization, identification or quantification of Factor VIII, von Willebrand's Factor or a protein that is a analogue of either, an affinity adsorbent is used that is a compound of formula (II) wherein one X is N and the other is N, C—Cl or C—CN; A is a support matrix, optionally linked to the triazine ring by a spacer; Y is O, S or NR2; Z is O, S or N—R3; R2and R3are each H, C1-6alkyl, C1-6hydroxyalkyl, benzyl or &bgr;-phenylethyl; B and W are each an optionally substituted hydrocarbon linkage containing from 1 to 10 carbon atoms; D is H, OH or a primary amino, secondary amino, tertiary amino, quaternary ammonium, imidazole, guanidino or amidino group; or B-D is —CHCOOH—(CH2)3-4—NH2; and R7is a group bearing a positive charge at neutral pH.

REFERENCES:
patent: 0 411 810 (1991-02-01), None
patent: WO 9710887 (1997-03-01), None
patent: WO 00/67900 (2000-11-01), None
Berg, Axel et al. “Dye-ligand centrifugal affinity chromatography.” Bioseparation (1990) 1 p. 23-31.
Burton et al., “Design of Novel Affinity Adsorbents for the Purification of Trypsin-like Proteases,”Journal of Molecular Recognition, 1992, vol. 5, pp. 55-68.
Lowe, “Combinatorial approaches to affinity chromatography,”Current Opinion in Chemical Biology, 2001, vol. 5, pp. 248-256.

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