Aerosol preparation for external use

Details Aerosol preparation for external use Aerosol preparation for external use

1990-11-13

1995-03-14

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Effervescent or pressurized fluid containing

Organic pressurized fluid

424 47, 424DIG1, 424 7803, A61K 912

Patent

active

053975642

DESCRIPTION:

BRIEF SUMMARY
TECHNICAL FIELD

This invention relates to an aerosol preparation for external use and more specifically, to an aerosol preparation for external cooling which propells a sherbet-like foam.


TECHNICAL BACKGROUND

In recent years, sporting activities have become more and more popular, and with it, injuries such as bruises and wrenches occur frequently, and in many cases, an emergency treatment requires the cooling of the affected part.
Emergency cooling of the affected part is conveniently performed by using an aerosol preparation for external use. Known aerosol agents include, for example, an external aerosol agent composed of a 9:1 mixture of trichloromonofluoromethane and dichlorodifluoromethane (Japanese Patent Publication No. 35797/1970), and an aerosol preparation for external use composed of an organic compound having a molecular weight of at least 80 and a latent heat of evaporation at 25.degree. C. of 20 to 100, filled in a container together with a compressed gas (Japanese Laid-Open Patent No. 86606/1979).
However, aerosol preparations of this type have only a transient cooling effect and its effect does not last long. Moreover since the concentrate and/or propellant uses chlorofluorocarbon, the use of these chemicals are undesirable as the adverse effects of the chlorofluorocarbons have come to be recognized
Furthermore, with this type of aerosol preparations the concentrate to be sprayed jets out as a fine mist, its adhesion to the affected part is poor, and the scattered concentrate presents the danger of inhalation by patients.


SUMMARY OF THE INVENTION

It is an object of this invention to provide a foam-forming aerosol preparation having a long-lasting cooling effect with a large amount of the concentrate to be applied without the need for using a fluorocarbon as a propellant.
In order to solve this problem, the present inventors made extensive investigations, and found that when a liquefied petroleum gas, dimethyl ether or a mixture of these gases is adjusted to a specified vapor pressure and used as a propellant and water or a mixture of water with a specified amount of a lower alcohol is used as a concentrate, blending this propellant and the concentrate in a specified ratio an aerosol agent is prepared which when sprayed, sticks to the applied part as a sherbet-like foam, and its cooling effect is high and lasts for a long time.
The aerosol preparation of this invention includes 20.degree. C. comprising a liquefied petroleum gas, dimethyl ether or a mixture of these gases, and thereof of a lower alcohol or only water, the weight ratio of (A) to (B) being from 95:5 to 50:50.
In the present invention, liquefied petroleum gas, dimethyl ether or a gaseous mixture of these gases is used as the propellant, and no chlorofluorocarbon, which is likely to destroy the ozone layer, is used.


DESCRIPTION OF THE PREFERRED EMBODIMENTS

The vapor pressure of the propellant should be maintained within the above-specified range, preferably within 2 to 4 kg/cm.sup.2.
If the concentrate is composed of water and a lower alcohol, the weight of water may be at least the weight of the lower alcohol. The preferred weight ratio of the alcohol to the water is from 95:5, preferably from 60:40.
The lower alcohols are those having 1 to 4 carbon atoms, preferably ethanol and isopropanol.
As required, there may be used anti-inflammatory agents (e.g., methyl salicylate, monoglycol salicylate, indomethacin, ketoprofen, dichlofenac, ibuprofen and mafenamic acid), antipruritic agents (e.g., ichthammol, mocthammol, thymolic acid, isothipendyl hydrochloride, diphenhydramine hydrochloride and chlorpheniramine), antifungicides (e.g., undecylenic acid, pentachlorophenol, clotrimazole, tolnaftate, trichomycin and miconazole nitrate), germicides (e.g., potassium iodide, chlorhexidine gluconate, acrinol and benzalkonium chloride), antipurulent agents (e.g., penicillin V, tetracycline hydrochloride, fradiomycin and kanamycin), refrigerants (e.g., l-menthol, camphor and mentha oil), anti-oxidants (e.g., BHT), solubilizing agents (

REFERENCES:
patent: 4536323 (1985-08-01), Stopper
patent: 4548807 (1985-10-01), Westfall et al.
Patent Abstracts of Japan, vol. 6, No. 11 (C-88) [889], 22nd Jan. 1982.
Patent Abstracts of Japan, vol. 13, No. 63 (C-568) [3411], 13th Feb. 1989.

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