Drug – bio-affecting and body treating compositions – Effervescent or pressurized fluid containing – Organic pressurized fluid
Patent
1992-02-11
1993-07-27
Page, Thurman K.
Drug, bio-affecting and body treating compositions
Effervescent or pressurized fluid containing
Organic pressurized fluid
424 43, 424 45D, 514 3, 514866, 514937, A61K 912, A61K 9127
Patent
active
052308847
ABSTRACT:
Highly purified and recombinantly produced polypeptides and proteins can be provided to a patient to treat systemic disorders using a metered dose inhaler (MDI). The polypeptides and proteins are solubilized in reverse micelles formed from the surfactant in the MDI propellant. By controlling the molar ratio of water to surfactant, the amount of polypeptide or protein solubilized in the reverse micelles can be controlled, thereby providing an accurate dosing mechanism. In addition, controlling the molar ratio of water to surfactant also can adjust the size and shape of the reverse micelles which will affect the degree and rate of penetration of the lung mucosa for delivery of the drugs to the patient's blood stream. Proteins which may particularly benefit from the solubilization and systemic delivery process include calcitonin, oxytocin, and insulin.
REFERENCES:
patent: 4814161 (1989-03-01), Jinks et al.
Singleterry et al., J. Am. Oil Chem. Soc., 32:446-452 (1955).
Byron, Ad. Drug Delivery Rev., 5:107-132 (1990).
Evans et al., J. Aerosol Sci. 20:1309 (1989).
Evans et al., J. Pharm. Pharmacol. 41:36 (1989).
Evans et al., J., Pharm. Pharmacol. 40:76 (1988).
Luisi et al., Biochimica Biophysica Acta., 947:209-246, (1988).
Appendix: Respiratory Drug Delivery, Peter Byron, Ed., CRC Press, Inc., 1990, pp. 249-253.
Evans Richard M.
Farr Stephen J.
Bawa Raj
Page Thurman K.
University of Wales College of Cardiff
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