Drug – bio-affecting and body treating compositions – Effervescent or pressurized fluid containing – Organic pressurized fluid
Patent
1996-05-10
1999-06-22
Bawa, Raj
Drug, bio-affecting and body treating compositions
Effervescent or pressurized fluid containing
Organic pressurized fluid
424 59, 424443, 424445, 424 7805, 424405, 424DIG10, 514937, 514919, 514834, A61K 912
Patent
active
059140984
DESCRIPTION:
BRIEF SUMMARY
BACKGROUND OF THE INVENTION
1. Field of the Invention
The field of the present invention is that of aerosol compositions and more particularly those consisting of propelled film-forming substances which are useful especially, but not exclusively, for the application of a curative protective film to lesions, for example skin lesions.
More precisely, the present invention relates to an aerosol composition for forming a preferably hydrated membrane.
The invention further relates to the preferably hydrated membrane obtained from the abovementioned aerosol composition.
Without implying a limitation, the invention relates more specifically to the application of this aerosol composition and this preferably hydrated membrane for the dressing of wounds, burns or the like.
2. Description of the Prior Art
The purpose of dressing these local traumatisms, often on the skin, is to protect them from the external environment so as to avoid bacterial contamination and allow rapid healing of high quality. To this end, the dressing should obviously be biocompatible so as to be perfectly tolerated, and should preferably be transparent so that the condition and progress of the traumatism can be checked easily.
It is also advantageous for the dressing to possess a degree of mechanical strength, to be permeable to water vapor and also to be easy and painless to apply and remove.
The most traditional dressing is the one consisting of gauze (optionally mounted on adhesive plastic tape). The major disadvantage of this type of dressing is that it adheres too strongly to the wound, whereby the changes of dressing, which are of necessity relatively frequent, are delicate and painful operations. Moreover, the dressed lesions are in most cases suppurant, causing obstruction of the gauze or similar dressing. The dressing consequently becomes impermeable, thereby detracting from the healing and curing of the lesion.
Propelled film-forming substances for dressings are also known which consist of aerosol compositions comprising an active polymer as the film-forming substance, said polymer being capable of forming, after vaporization, a biocompatible film which adheres conveniently to the skin and is transparent and elastic, to name only some of the abovementioned properties expected for application as a dressing.
A wide variety of aerosol compositions containing a film-forming polymer have already been proposed. The following examples may be mentioned: acid (cf. FR-A-1 589 917), associated with a propellant gas (cf. FR-A-2 589 737), cellulose, polyvinylbutyral, an ethylene oxide copolymer or a polyisobutylene in solution in solvent such as butanol (cf. FR-A-2 219 793 and FR-A-2 212 134), compounds bonded to organic polymers such as polyvinylpyrrolidone or cellulose acrylate or methacrylate, associated with a solvent propellant (cf. U.S. Pat. No. 4,921,691).
The constituent polymers of these known aerosol compositions have the disadvantage of producing non-hydrated films which are not entirely satisfactory in terms of healing. Moreover, it is clear that, in all probability, these polymers comprise unnatural residual monomers which are capable of generating inflammatory reactions on account of their toxicity towards a living medium (e.g. acrylic derivatives and siloxanes).
In an attempt to improve these vaporizable aerosol compositions for dressings, EP-A-0 521 455 has proposed replacing the known, imperfect film-forming polymers with a biodegradable hydroxycarboxylic acid polymer. The polymer in question can be a polylactic and/or polyglycolic polymer dissolved in a propellant solvent such as dimethyl ether, a freon, a gaseous alkane (e.g. liquefied propane) or an analog of said solvents. This aerosol composition also comprises water and an alcohol such as ethanol, which is useful as a solvent for various therapeutic active principles which may be present.
Despite the advantages of their biocompatibility and biodegradability, these hydroxycarboxylic acid polymers suffer from a serious shortcoming associated with the quality of the film they
REFERENCES:
patent: 4920158 (1990-04-01), Murray et al.
Castan Catherine
Grosselin Jean-Michel
Jorda Rafael
Soula Gerard
Bawa Raj
Flamel Technologies
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