Chemistry: molecular biology and microbiology – Differentiated tissue or organ other than blood – per se – or... – Including freezing; composition therefor
Reexamination Certificate
2005-03-11
2010-06-22
Saucier, Sandra E (Department: 1651)
Chemistry: molecular biology and microbiology
Differentiated tissue or organ other than blood, per se, or...
Including freezing; composition therefor
Reexamination Certificate
active
07741018
ABSTRACT:
Disclosed herein are aqueous carrier solutions for cryoprotectants that are useful for a variety of cryoprotectant solutions for use with cells, tissues, and whole organs, said aqueous carrier solutions permitting antinucleators to be fully effective in vitrification solutions, thereby allowing vitrification solutions to attain extreme effectiveness, and compatible vitrification solution compositions for use with these carrier solutions. The carrier solutions comprise lactose, mannitol or trehalose, and glucose in combination with other beneficial ingredients.
REFERENCES:
patent: 5364756 (1994-11-01), Livesey et al.
patent: 5800978 (1998-09-01), Goodrich, Jr. et al.
patent: 5879875 (1999-03-01), Wiggins et al.
patent: 6194137 (2001-02-01), Khirabadi et al.
patent: 6395467 (2002-05-01), Fahy et al.
patent: 6869757 (2005-03-01), Fahy
patent: 2002/0045156 (2002-04-01), Toner et al.
patent: 1-106826 (1989-04-01), None
patent: WO 97/45010 (1997-12-01), None
patent: WO 97/47192 (1997-12-01), None
patent: WO 99/60849 (1999-12-01), None
patent: WO 00/16619 (2000-03-01), None
patent: WO 01/42388 (2001-06-01), None
Merck Index, entry 56, 1989.
Williams et al., “Vial Breakage by Frozen Mannitol Solutions: Correlation with Thermal Characteristics and Effect of Stereoisomerism, Addivitves and Vial Configuration”, J. Parenteral Science & Technology 45 (2) : 94-100 (1991).
Ren et al., “The Crystallization Kinetics and the Critical Cooling Rates for Vitrification of Cryoprotective Solutions”, Cryogenics 30:536-40 (1990).
Klebe et al., “Identification of new cryoprotective agents for cultured mammalian cells”, In Vitro 19(3 part I) : 167-70 (1983).
Fahy et al., “Some emerging principles underlying the physical properties, biological actions, and utility of vitrification solutions.” Cryobiology, Academic Press Inc., 24(3): 196-213, 1987.
International Search Report for PCT Application No. PCT/US01/23853.
Fahy, Gregory M. and Ali, Suja E., Cryopreservation of the Mammalian Kidney,Cryobiology, 35: 114-1131, 1997.
Kheirabadi. Bijan S. and Fahy, Gregory M., Permanent Life Support by Kidneys Perfused with a Vitrifiable (7.5 Molar) Cryoprotectant Solution,Transplantation, 70: 51-57, 2000.
Khirabadi. Bijan S. and Fahy, Gregory M., Cryopreservation of the Mammalian Kidney—Transplantation of Rabbit Kidneys Perfused with EC and RPS-2 at 2-4°C1,Cryobiology, 31: 10-25, 1994.
Kirabadi, B. S., Fahy, G.M., Merei, J., and Rasch, C., Does Substitution of Mannitol for Glucose Improve Euro-Collins as a Vehicle for Cryoprotective Agents?,Cryobiology, 35: 357, 1997.
“paper submitted for publication, 2001”, Arnaud, Francoise, Khirabadi, Bijan S., Fahy, Gregory M., Normothermic blood perfusion of isolated rabbit kidneys,Transpl Int, 15: 278-289, 2002.
Fahy, Gregory M. et al., Cellular Injury Associated with Organ Cryopreservation: Chemical Toxicity and Cooling Injury,Cell Biology of Trauma, CRC Press, Boca Raton, Chapter 20: 333-356, 1995.
Rall, W. F. and Fahy, G. M., Ice-free cryopreservation of mouse embryos at—196°C by vitrification,Nature, 313: 573-575, 1985.
Williams et al., Vial breakage by frozen Mannitol solutions: Correlation with thermal characteristics and effect of stereoisomerism, additives and vial configuration. J. Parenteral Science 7 Technology, 45(2): 94-100, 1991.
Ren et al., The Crystallization kinetics and the critical cooling rates for vitrification of cryoprotective solutions. Cryogenics, 30:536-540, 1990.
Klebe et al., Identification of new cryoprotective agents for cultured mammalian cells. In Vitro, 19(3 Part 1): 167-170, 1983.
Fahy, Gregory M. and Ali, Suja E., Cryopreservation of the Mammalian Kidney,Cryobiology, 35:114-1131, 1997.
Kheirabadi, Bijan S. and Fahy, Gregory M., Permanent Life Support By Kidneys Perfused with a Vitrifiable (7.5 Molar) Cryoprotectant Solution,Transplantation, 70: 51-57, 2000.
Khirabadi, Bijan S. and Fahy, Gregory M., Cryopreservation of the Mammalian Kidney—Transplantation of Rabbit Kidneys Perfused with EC and RPS-2 at 2-4°C1Cryobiology, 31: 10-25, 1994.
Kirabadi, B. S., Fahy, G.M., Merei, J., and Rasch, C. Does Substitution of Mannitol for Glucose Improve Euro Collins as a Vehicle for Cryoprotective Agents?,Cryobiology, 35: 357, 1997.
“paper submitted for publication, 2001”, Arnaud, Francoise, Khirabadi, Bijan S., Fahy, Gregory M., Nomothermic blood perfusion of isolated rabbit kidneys,Transpl Int, 15: 278-289, 2002.
Fahey, Gregory M. et al., Cellular Injury Associated with Organ Cryoperservation: Chemical Toxicity and Cooling Injury,Cell Biology of Trauma, CRC Press, Boca Raton, Chapter 20: 333-356, 1995.
Rall, W. F. and Fahy, G. M., Ice-free cryopreservation of mouse embryos at 196°C by vitrification,Nature, 313: 573-575, 1985.
21st Century Medicine, Inc.
Foley & Lardner LLP
Reiter Stephen E.
Saucier Sandra E
LandOfFree
Advantageous vitrifiable cryoprotectant mixtures does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Advantageous vitrifiable cryoprotectant mixtures, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Advantageous vitrifiable cryoprotectant mixtures will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4151578