Electricity: measuring and testing – Particle precession resonance – Spectrometer components
Reexamination Certificate
2006-01-24
2006-01-24
Shrivastav, Brij B. (Department: 2859)
Electricity: measuring and testing
Particle precession resonance
Spectrometer components
C324S318000
Reexamination Certificate
active
06989674
ABSTRACT:
The present invention relates to a probe and processes useful for magnetic resonance imaging and spectroscopy instruments. More particularly, the invention relates to a MR probe and processes for obtaining resolution enhancements of fluid objects, including live specimens, using an ultra-slow (magic angle) spinning (MAS) of the specimen combined with a modified phase-corrected magic angle turning (PHORMAT) pulse sequence. Proton NMR spectra were measured of the torso and the top part of the belly of a female BALBc mouse in a 2T field, while spinning the animal at a speed of 1.5 Hz. Results show that even in this relatively low field with PHORMAT, an isotropic spectrum is obtained with line widths that are a factor 4.6 smaller than those obtained in a stationary mouse. Resolution of1H NMR metabolite spectra are thus significantly enhanced. Results indicate that PHORMAT has the potential to significantly increase the utility of1H NMR spectroscopy for in vivo biochemical, biomedical and/or medical applications involving large-sized biological objects such as mice, rats and even humans within a hospital setting. For small-sized objects, including biological objects, such as excised tissues, organs, live bacterial cells, and biofilms, use of PASS at a spinning rate of 30 Hz and above is preferred.
REFERENCES:
patent: 5208536 (1993-05-01), Cory
patent: 5298864 (1994-03-01), Muller et al.
patent: 5754048 (1998-05-01), Bielecki
patent: 5872452 (1999-02-01), Cory et al.
patent: 2002/0125887 (2002-09-01), Wind et al.
patent: 2003/0052678 (2003-03-01), Gerald, II et al.
patent: 2003/0102867 (2003-06-01), Hioka
patent: 0 562 865 (1993-09-01), None
Ericsson A, Weis J, Hemmingsson A, Wikstrom M, and Sperber GO, Measurements of magnetic-field variations in the human brain using a 3D-FT multiple gradient-echo technique. Magn. Reson Med. 1995; 33: 171-177.
Yablonskiy DA, Quantitation of intrinsic magnetic susceptibility-related effects in a tissue matrix. Phantom study. Magn. Reson. Med. 1998; 39: 417-428.
Boxerman JL, Weisskopf RM, and Rosen BR, Susceptibility effects in whole body experiments. In: Young IR, editor. Methods in biomedical magnetic resonance imaging and spectrscopy. New York: John Wiley & Sons; 2000. p 654-661.
Kreis R., Quantitative localized1H MR spectroscopy for clinical use, J. Progr. in NMR Spectr. 1997; 31: 155-195.
Garrod S, Humpfer E, Spraul M, Connor SC, Polley S, Connelly J, Lindon JC, Nicholson JK and Holmes E. High-resolution magic angle spinning1H NMR spectroscopic studies on intact rat renal cortex and medulla. Magn Reson Med 1999; 41: 1108-1118.
Bollard ME, Garrod S, Holmes E, Lindon JC, Humfer E, Spraul M and Nicholson JK. High-resolution1H and1H-13C magic angle spinning NMR spectroscopic of rat liver. Magn Reson Med 2000; 44: 201-207.
Andrew ER, Eades RG. Removal of dipolar broadening of NMR spectra of solids by specimen rotation. Nature 1959; 183: 1802.
Garroway AN. Magic-angle sample spinning of liquids. J. Magn Reson 1982; 49: 168-171.
VanderHart DL. Magnetic susceptibility & high resolution NMR of liquids & solids. In: Grant DM Harris RK, editors. Encyclopedia of nuclear magnetic resonance. New York: John Wiley & Sons; 1996. p 2938-2946.
Weybright P, Millis K Campbell N, Cory DG, and Singer S, Gradient, high-resolution, magic angle spinning1H nuclear magnetic resonance spectroscopy of intact cells, Magn. Reson. Med. 1998; 39: 337-345.
Chen J, Enloe BM, Fletcher CD, Cory DG, Singer S. Biochemical Analysis Using High-Resolution Magic Angle Spinning NMR Spectroscopy Distinguishes Lipoma-like Well-differentiated Liposarcoma from Normal Fat. J Am Chem Soc 2001; 123: 9200-9201.
Garrod S, Humpher E, Connor SC, Connelly JC, Spraul M, Nicholson JK, and Holmes E. High-resolution1H NMR and magic angle spinning NMR spectroscopy investigation of the biochemical effects of 2-bromoethanamine in intact renal and hepatic tissue. Magn Reson Med 2001; 45: 781-790.
Wind RA, Hu JZ, and Rommereim DN, High Resolution1H NMR Spectroscopy in Organs and Tissues Using Slow Magic Angle Spinning, Magn. Reson. Med. 2001; 46: 213-218.
Hu JZ, Rommereim DN, and Wind RA, High Resolution1H NMR Spectroscopy in Rat Liver Using Magic Angle Turning at a 1 Hz Spinning Rate, Magn. Reson. Med. 2002; 47: 829-836.
Hu JZ and Wind RA, The evaluation of different MAS techniques at low spinning rates in aqueous samples and in the presence of magnetic susceptibility gradients, J. Magn. Reson. 2002; 159: 92-100.
Oyama AJ, Response and adaptation of Beagle dogs to hypergravity, Life sciences and space research XIII: Proc. of the 17thplenary meeting, Sao Paulo, Brazil 1974, Akademie-Verlag, Berlin, 1975. p. 11-17.
Hu Jian Zhi
Minard Kevin R.
Rommereim Donald N.
Wind Robert A.
Battelle (Memorial Institute)
Matheson James D.
Shrivastav Brij B.
LandOfFree
Advanced slow-magic angle spinning probe for magnetic... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Advanced slow-magic angle spinning probe for magnetic..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Advanced slow-magic angle spinning probe for magnetic... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3545317