Chemistry: molecular biology and microbiology – Vector – per se
Reexamination Certificate
2006-11-21
2006-11-21
Housel, James C. (Department: 1648)
Chemistry: molecular biology and microbiology
Vector, per se
C424S185100, C424S192100, C424S202100, C424S217100
Reexamination Certificate
active
07138274
ABSTRACT:
The present invention relates to a novel recombinant Sabin type 1 poliovirus vector for the immunogenicity of neutralizing antibody against polioviral infection, which comprises: (a) a genomic nucleotide sequence of a parent Sabin type 1 poliovirus; (b) a nucleotide sequence encoding an additional polioviral cleavage site; and (c) a nucleotide sequence of a conformational epitope encoding a VP1 neutralizing epitope of poliovirus type 2 or 3 and linked to the nucleotide sequence of (b).
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Ren, R. et al., Transgenic mice expressing a human poliovirus receptor: a new model for poliomyelitis. Cell. Oct. 19, 1990;63(2):353-62.
Crotty, S. et al., Poliovirus pathogenesis in a new poliovirus receptor transgenic mouse model: age-dependent paralysis and a mucosal route of infection. J Gen Virol. Jul. 2002;83(Pt 7):1707-20.
“Immnization Schedule, Children; Poliovirus” at http://emedicinehealth.com/articles/11995-5.asp accessed on Monday, Mar. 14, 2005 at 1:30 P.M.
Delpeyroux, F. et al. Presentation and immunogenicity of the hepatitis B surface antigen and a poliovirus neutralization antigen on mixed empty envelope particles. J virol. May 1988;62(5):1836-9.
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Bae Yong-Soo
Jeong Hye-Rhan
Kim Dae-You
Kim Ki-Tae
Lee Dong-Sung
Creagene, Inc.
Housel James C.
Salvoza M. Franco
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