Advanced glycosylation endproducts and associated methods

Details Advanced glycosylation endproducts and associated methods Advanced glycosylation endproducts and associated methods

1991-01-08

1992-06-30

Griffin, Ronald W.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

435 18, 435975, 435971, 435972, 435 6, 435 71, 435 14, 435 79, 435 791, 530356, 530362, 436545, 436546, 436 86, 436504, 436543, 422 61, 424 59, 252646, 252645, 252700, C07D40514, A61K 742, A61K 743, A61K 3140

Patent

active

051264420

ABSTRACT:
New and useful chromophores have been isolated from the reaction mixture of proteins exposed to reducing sugars in the presence of sulfite over time. The chromophores are believed to be intermediates in nonenzymatic polypeptide glycosylation. The measurement of this chromophore makes possible both qualitative and quantitative assessment of the presence of nonenzymatic browning. Diagnostic and test kits are also disclosed.

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Farmar et al., J. Oganic Chemistry, 53, 2346 (1988).
"Umsetzung Von Rebuzierenden Zuchern Mit Alkylaminen Als Beitrag Zur Kenntnis Der Maillard-Reaktion," Ph.D. Thesis of Ulrich Kronig, Munich, 1974 (and partial translation).
"Kondensation Von Xylose Mit Methylammoniumacetat," Th. Severin and U. Kronig (and translation).

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