Advanced glycosylation end products and associated methods

Details Advanced glycosylation end products and associated methods Advanced glycosylation end products and associated methods

1989-12-20

1991-05-21

Griffin, Ronald W.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

530356, 530362, 424 59, 422 61, 436546, 436504, 436 86, 436543, 514838, 514885, 436545, C07D40514, A61K 742, A61K 743, A61K 3140

Patent

active

050176960

ABSTRACT:
New and useful chromophores have been isolated from the reaction mixture of proteins exposed to reducing sugars in the presence of sulfite over time. The chromophores are believed to be intermediates in nonenzymatic polypeptide glycosylation. The measurement of this chromophore makes possible both qualitative and quantitative assessment of the presence of nonenzymatic browning. Diagnostic and test kits are also disclosed.

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"Umsetzung Von Rebusierenden Zuchern Mit Alkylaminen Als Beitrag Zur Kenntnis Der Maillard-Reaktion," Ph.D. Thesis of Ulrich Kronig, Munich, 1974 (and partial translation).
"Kondensation Von Xylose Mit Methylammoniumacetat," Th. Severin and U. Kronig (and Translation).

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