Advanced glycation inhibitors containing amino-benzoic acids and

Details Advanced glycation inhibitors containing amino-benzoic acids and Advanced glycation inhibitors containing amino-benzoic acids and

1992-06-12

1993-12-21

Waddell, Frederick E.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ester doai

514561, 514565, 514567, 514613, 514617, 514399, 514866, 514913, 514400, 514632, A61K 3124, A61K 31195, A61K 31415

Patent

active

052721760

ABSTRACT:
The present invention relates to compositions and methods for inhibiting nonenzymatic cross-linking (protein aging). Accordingly, a composition is disclosed which comprises an agent capable of inhibiting the formation of advanced glycosylation endproducts of target proteins by reacting with the carbonyl moiety of the early glycosylation product of such target proteins formed by their initial glycosylation. The method comprises contacting the target protein with the composition. Both industrial and therapeutic applications for the invention are envisioned, as food spoilage and animal protein aging can be treated.

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