Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of... – Solid support and method of culturing cells on said solid...
Reexamination Certificate
2007-12-11
2007-12-11
Prouty, Rebecca E. (Department: 1652)
Chemistry: molecular biology and microbiology
Animal cell, per se ; composition thereof; process of...
Solid support and method of culturing cells on said solid...
C435S189000, C435S184000, C435S069700, C424S094400, C424S400000
Reexamination Certificate
active
10488743
ABSTRACT:
The present invention provides a fusion protein which delivers a functional protein or peptide into a cell at enhanced efficiency. The fusion protein of the present invention is a transduction domain-target protein-transduction domain fusion protein, wherein the transduction domain, which comprises 6-12 amino acid residues whose more than ¾ consist of arginine or lysine residues, is covalently bonded to each of the amino- and carboxyl-terminal ends of the target protein. Green fluorescence protein and Cu/Zn-superoxide dismutate (SOD) are used as the target protein.
REFERENCES:
patent: 2004/0043463 (2004-03-01), Rao
patent: 2006/0141598 (2006-06-01), Terlecky et al.
Park et al. (Molecul. Cells . (2002) 13 , pp. 202-208).
Choi Jin-Hee
Choi Su-Young
Han Kyu-Hyung
Park Jin-Seo
Meah Md. Y.
Nelson Mullins Riley & Scarborough LLP
Polymer Ventures, Inc.
Prouty Rebecca E.
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