Adult T cell leukemia virus antigen polypeptide

Details Adult T cell leukemia virus antigen polypeptide Adult T cell leukemia virus antigen polypeptide

1985-01-29

1988-02-09

Foelak, Morton

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

530806, 530808, 530820, 530825, 435 68, 435 70, 935 47, 935 65, 424 89, C07K 1300, C12P 2102

Patent

active

047242582

ABSTRACT:
Recombinant plasmids are constructed by inserting a DNA fragment containing the env gene of adult T cell leukemia virus or a part thereof into a vector DNA. Microorganisms are transformed with the recombinant plasmid and thereafter cultured to express the peptide. The antigen polypeptide encoded by the env gene is useful for the detection and diagnosis of adult T cell leukemia.

REFERENCES:
patent: 4520113 (1985-05-01), Gallo et al.
patent: 4572800 (1986-02-01), Shimizu et al.
Kiyokawa et al., "Env Protein of HTLU" PNAS, 81 1984, pp. 6202-6206.
Franchini et al., "HTLV Transcrips-Leukemia" PNAS 81 1984, pp. 6707-6711.
Weinstock et al., "Open Reading Frame Expression Vectors" PNAS, vol. 80, 1983, pp. 4432-4436.
Germino et al., "Use of Gene Fusion and Proteins-Protein Interaction . . . Plasmid R6K" PNAS, vol. 80, 1983, pp. 6848-6852.
Casadaban et al., J. Bacteriology, vol. 143(2) 1980, pp. 971-980.
Yoshida et al., PNAS 79, 1982, pp. 2031-2035.
Manzari et al., PNAS 80, 1983, pp. 1574-1578.
Oroszlan et al., PNAS 79, 1982, pp. 1291-1294.
Hinuma et al., PNAS 78(10) 1981, pp. 6476-6480.
Hattori, et al., Gann, 74, No. 6, Dec. 1983; 790-3.
Seiki, et al., P.N.A.S., 80, Jun. 1983: 3618-22.

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