Adult T cell leukemia model animal

Details Adult T cell leukemia model animal Adult T cell leukemia model animal

2007-03-06

2007-03-06

Qian, Celine (Department: 1636)

Multicellular living organisms and unmodified parts thereof and

Nonhuman animal

The nonhuman animal is a model for human disease

C435S325000, C800S003000

Reexamination Certificate

active

10319564

ABSTRACT:
The present invention provides an adult T cell leukemia model animal, which is a T cell function deficient animal to which a cell line infected with human T cell leukemia virus-1 is transplanted. This model animal allows the HTLV-1 infected cell line to proliferate over a long period of time, and enables not only the tumorigenesis process but also the mechanism of onset of ATL and immune response mechanism of the host against ATL to be precisely analyzed.

REFERENCES:
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Ohashi et al., “Induction of Adult T-Cell Leukemia-Like Lymphoproliferative disease and its Inhibition by Adoptive Immunotherapy in T-Cell-Deficient Nude Rats Inoculated with Syngeneic . . . ”, Journal of Virology, pp. 6031-6040, (1999).

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