Adult schistosome worm-derived antigenic substance and method of

Details Adult schistosome worm-derived antigenic substance and method of Adult schistosome worm-derived antigenic substance and method of

1980-12-18

1983-08-02

Fagelson, Anna P.

Drug, bio-affecting and body treating compositions

Lymphokine

260112R, 424 85, 424 93, 424177, 436515, A61K 39002

Patent

active

043966004

ABSTRACT:
An extract of adult Schistosome mansoni worms, obtained by incubation in 0.15 M sodium chloride-sodium phosphate buffer (pH 6.8), contains protein, carbohydrates, and nucleic acid and/or by-products of the latter component and resolves into four major fractions by gel chromatography in G-100 and G-200 Sephadex columns. Immunodiffusion tests with rabbit anti-total extract serum reveal three precipitation lines corresponding to fractions I and II, and one with III or IV. Rabbits immunized with this total extract are found to be totally or partially (at least 77%) resistant to a challenge infection. The saline extract antigenic material is an effective vaccine for the treatment and immunization of schistosomiasis and other schistosome infections.

REFERENCES:
patent: 4150107 (1979-04-01), Enders
patent: 4158049 (1979-06-01), Pelley
Madison, J. Parasit, vol. 64, No. 6, 1978, pp. 986-993.
Pelley, Am. J. Trop. Med. Hyg., vol. 26, 1977, pp. 104-112.
Boctor, J. Immunology, vol. 122, No. 1., Jan. 1979, pp. 39-43.
Carter, J. Immunology, vol. 122, No. 6, Jun. 1979, pp. 2204-2209.
Harrison, J. Immunology, vol. 122, No. 6, Jun. 1979, pp. 2210-2217.
Sadun, Military Med., vol. 124, 1959, pp. 428-436.

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