Adult human dental pulp stem cells in vitro and in vivo

Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C435S378000

Reexamination Certificate

active

07052907

ABSTRACT:
The present invention provides a culture of isolated adult human dental pulp stem cells that can differentiate into dentin/pulp tissue that can be used to produce a tooth in a human being. The present invention further provides a method of regenerating human dentin/pulp tissue.

REFERENCES:
patent: 5885829 (1999-03-01), Mooney et al.
patent: 6767740 (2004-07-01), Sramek et al.
patent: 6899915 (2005-05-01), Yelick et al.
patent: 2005/0019911 (2005-01-01), Gronthos et al.
patent: 2005/0053585 (2005-03-01), Black et al.
patent: 2005/0079470 (2005-04-01), Rutherford et al.
patent: 2005/0106724 (2005-05-01), Schierholz et al.
Bin P. Mineralization of Human Dental Pulp Cells in Continued Culture. Chinese J Stomatology 32(5)285-7, Sep. 1997.
Boh. K. Role Synthetic Extracellular Matrix in Development of Engineered Dental Pulp. J Biomaterial Science Polymer Edition 9(7)749-764, 1998.
Inoue T. Induction of Cartilage and Bone Formation by Cells from Explants of Various Oral Tissues in vitro. Bull Tokyo Dental College. 31(4)295-300, Nov. 1990.
Azizi et al. Engraftment and migration of human bone marrow stromal cells implanted in the brains of albino rats—similarities to astrocyte grafts.Proc Natl Acad Sci USA95:3908-3913 (1998).
Bennett et al. Adipocytic cells cultured from marrow have osteogenic potential.Journal of Cell Science99:131-139 (1991).
Bianco et al. (1998) The bone marrow stroma in vivo: ontogeny, structure, cellular composition and changes in diseases., eds. Owen, M.A. & Beresford, J.N. (Cambridge University Press, Cambridge, UK), pp. 10-25.
Bianco et al. Uno, nessuno e centomila: searching for the identity of mesodermal progenitors.Experimental Cell Research251:257-263 (1999).
Bianco et al. Marrow stromal stem cells.Journal of Clinical Investigation105(12):1663-1668 (2000).
Buurma et al. Transplantation of human pulpal and gingival fibroblasts attached to synthetic scaffold.Eur J Oral Sci107(4):282-289. (1999).
Casasco et al. Cell proliferation in developing human dental pulp: a combined flow cytometric and immunohistochemical study.European Journal of Oral Sciences, Denmark, Dec. 1997, vol. 105(6):609-613.
Cheng et al. Differentiation of human bone marrow osteogenic stromal cellsin vitro: induction of the osteoblast phenotype by dexamethasone.Endocrinology134: 277-286 (1994).
Couble et al. Odontoblast differentiation of human dental pulp cells in explant cultures.Calcif Tissue Int66:129-138 (2000).
Doetsch et al. Subventricular zone astrocytes are neural stem cells in the adult mammalian brain.Cell97:703-716 (1999).
Doherty et al. Vascular pericytes express osteogenic potential in vitro and in vivo.Journal of Bone and Mineral Research13(5):828-838 (1998).
Feng et al. Genomic organization, chromosomal mapping, and promoter analysis of the mouse dentin sialophosphoprotein (Dspp) gene, which codes for both dentin sialoprotein and dentin phosphoprotein. (1998)Journal of Biological Chemistry273(16):9457-9464 (1998).
Ferrari et al. Muscle regeneration by bone marrow-derived myogenic progenitors.Science279:1528-1530 (1998).
Friedenstein. Stromal mechanisms of bone marrow: cloning in vitro and retransplantation in vivo.Immunology of Bone Marrow Transplantation(Springer-Verlag, Berlin), pp. 19-29 (1980).
Friedenstein et al. Origin of bone marrow stromal mechanocytes in radiochimeras and heterotopic transplants.Exp Hematol6:440-444 (1978).
Gorter de Vries et al. Characterization and immunocytochemical localization of dentine phosphoprotein in rat and bovine teeth.Archives Oral Biology31(1):57-66 (1986).
Gronthos et al. The STRO-1 fraction of adult human bone marrow contains the osteogenic precursors.Blood84(12):4164-4173 (1994).
Gronthos et al. Postnatal human dental pulp stem cells (DPSCs) in vitro and in vivo.Proceedings of the National Academy of Sciences of the United States, Dec. 2000, vol. 97 No. 25, pp. 13625-13630, no date given.
Holtgrave et al. Response of odontoblast-like cells to hydroxyapatite ceramic granules.Biomaterials16:155-159 (1995).
Ishizeki et al. Calcification capacity of dental papilla mesenchymal cells transplanted in the isogenic mouse spleen.Anat Rec226(3):279-287 (1990.
Johansson et al. Rapid communication neural stem cells in the adult human brain.Experimental Cell Research253:733-736 (1999).
Kettunen et al. Responsiveness of developing dental tissues to fibroblast growth factors: expression of splicing alternatives of FGFR1, -2, -3, and of FGFR4; and stimulation of cell proliferation by FGF-2, -4, -8, and -9Developmental Genetics22:374-385 (1998).
Kitamura et al. Temporal and spatial expression of c-jun and jun-B proto-oncogenes in pulp cells involved with reparative dentinogenesis after cavity preparation of rat molars.J Dent Res78:673-680 (1999).
Kuo et al. Collagen gene expression in human dental pulp cell cultures.Archives of Oral Biology37(11):945-952 (1992).
Kuznetsov et al. Single-colony derived strains of human marrow stromal fibroblasts form bone after transplantation in vivo. (1997)Journal of Bone and Mineral Research12:1335-1347 (1997).
Lennon et al. A chemically defined medium supports in vitro proliferation and maintains the osteochondral potential of rat marrow-derived mesenchymal stem cells.Experimental Cell Research; U.S., Jul. 1995, vol. 219 No. 1, pp. 211-222.
Lyaruu et al. Development of transplanted pulp tissue containing epithelial sheath into a tooth-like structure.J Oral Pathol Med28(7):293-296 (1999).
MacDougall et al. Dentin phosphoprotein and dentin sialoprotein are cleavage products expressed froma single transcript coded by a gene on human chromosome 4 (1997)Journal of Biological Chemistry272(2):835-842.
Magloire et al. An in vitro model of human dental pulp repair.Journal of Dental Research, U.S., Dec. 1996, vol. 75 No. 12, pp. 1971-1978.
Majors et al. Characterization of human bone marrow stromal cells with respect to osteoblastic differentiation .J Orthop Res15(4):546-557 (1997).
Nakashima et al. Regulatory role of transforming growth factor-β, bone morphogenetic protein-2, and protein-4 on gene expression of extracellular matrix proteins and differentiation of dental pulp cells.Developmental Biology162:18-28 (1994).
Onishi et al. Stimulation of proliferation and differentiation of dog dental pulp cells in serum-free culture medium by insulin-like growth factor.Archives of Oral Biology44:361-371 (1999).
Owen. The marrow stromal cell system.Marrow Stromal Cell Culture. (Cambridge University Press, Cambridge), pp. 1-9 (1998).
Pittenger et al. Multilineage potential of adult human mesenchymal stem cells.Science284:143-147 (1999).
Prime et al. Xenografts of human ameloblastoma tissue and odontogenic mesenchyme to hypothymic mice.Transplantation33(5):561-562 (1982).
Ritchie et al. Cloning and sequence determination of rat dentin sialoprotein, a novel dentin protein.Journal of Biological Chemistry269(5):3698-3702 (1994).
Robey. Stem cells near the century mark.Journal of Clinical Investigation105(11):1489-1491 (2000).
Ruch. Odontoblast commitment and differentiation.Biochem Cell Biol76:923-938 (1998).
Schultz et al. Skeletal muscle satellite cells.Rev Physiol Biochem Pharmacol123:213-257 (1994).
Shiba et al. Effects of basic fibroblast growth factor on proliferation, the expression of osteonectin(SPARC) and alkaline phosphatase, and calcification in cultures human pulp cells.Developmental Biology170:457-466 (1995).
Shiba et al. Differential effects of barious growth factors and cytokines on the syntheses of DNA, type I collagen, laminin, fibronectin, osteonectin/secreted protein, acidic and rich in cysteine (SPARC), and alkaline phosphatase by human pulp cells in culture.Journal of Cell Physiology174:194-205 (1998).
Smith et al. Reactionary dentinogenesis.Int J Dev Biol39:273-280 (1995).
Stanislawski et al. In vitro culture of human dental pulp cells: some aspects of cells emerging early from the explant.Clinical Oral Investigations, Germany, Sep. 1997, vol. 1 No. 3, pp. 131-140.
Tsukamoto et al. Mineralized nodule formation by cultures of human dental pulp-derived fibroblasts.Archives of Oral Biology37(12):1045

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Adult human dental pulp stem cells in vitro and in vivo does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Adult human dental pulp stem cells in vitro and in vivo, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Adult human dental pulp stem cells in vitro and in vivo will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3538136

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.