Adsorbents for amino acid and peptide separation

Synthetic resins or natural rubbers -- part of the class 520 ser – Synthetic resins – Mixing of two or more solid polymers; mixing of solid...

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5253303, 525 5411, C08F 1208, C08F11208, C08F21208, C08F 2010

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active

057864284

ABSTRACT:
An adsorbent which selectively binds to one enantiomer of an optically active amino acid or peptide. The adsorbent includes a polymer matrix which contains one or more metal complexes that are oriented within the polymer matrix by molecular imprinting to provide selective binding of the matrix to only one enantiomer of the optically active amino acid or peptide. Separation systems are disclosed which use the adsorbent as the basis for conducting enantioresolution of optically active amino acids and peptides. Methods for using the adsorbent are also disclosed.

REFERENCES:
patent: 5310648 (1994-05-01), Arnold et al.
patent: 5541342 (1996-07-01), Korhonen et al.
Rogozhin et al. "Ligand Chromatography On Assymetric Complex-forming Sorbents As A New Method For Resolution Of Racemates," Chemical Communications, p. 490 (1971).
Lefebvre et al., "Use Of New Chiral Hydrophilic Gels For The Direct Resolution .alpha.-Aminoacids By High Pressure Liquid Chromatography," J. Liquid Chromatography, 1(6), 761-774 (1978).
Galaverna et al. "Chiral Separation Of Unmodified Amino Acids By Ligand-Exchange High-Performance Liquid Chromatography Using Copper (II) complexes of .sub.L -Amino Acid Amides As Additives To The Eluent," J. Chromatography A., 657 (1993) 43-54.
Sellergren et al., "Highly Enantioselective And Substrate-Selective Polymers Obtained By Molecular Imprinting Utilizing Noncovalent Interactions. NMR and Chromatographic Studies On The Nature Of Recognition," J. Am. Chem. Soc. 1988, 110, 5853-5860.
Andersson et al., "Imprinting Of Amino Acid Derivatives In Macroporous Polymers," Tetrahedron Letters, vol. 25, No. 45, pp. 5211-5214, 1984.
Kempe et al., "Binding Studies On Substrate-And Enantio-Selective Molecularly Imprinted Polymers," Analytical Letters, 24(7), 1137-1145 (1991).
Dhal, "Surface Grafting Of Functional Polymers To Macroporous Poly(trimethylolpropane trimethoacrylate)," Chem. Mater. 1995, 7, 154-162.
Dhal et al., "Metal-Coordination Interactions In The Template-Mediated Synthesis Of Substrate-Selective Polymers: Recognition Of Bis(imidazole) Substrates By Copper (II) Iminodiacetate Containing Polymers," Macromolecules 1992, 25, 7051-7059.
Sellergren et al., "Influence Of Polymer Morphology On The Ability Of Imprinted Network Polymers To Resolve Enantiomers," J. Chromatography, 635 (1993) 31-49.
Plunkett et al., "Molecularly Imprinted Polymers On Silica: Selective Supports For High Performance Ligand-Exchange Chromatographyyy," J. Chromatography A., 708 (1995) 19-29.

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