Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Patent
1991-07-12
1993-06-01
Rollins, John W.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
530386, 530415, 514553, 514554, 514647, 514649, 514679, A61K 3514, A61K 31185, A61K 31205, A23J 100
Patent
active
052161277
ABSTRACT:
An adsorbent for a serum amyloid protein, which includes a water-insoluble carrier and either a compound selected from a compound having an anionic functional group, a polyanionic compound having more than one anionic functional groups, aniline and an aniline derivative, the compound being immobilized onto the carrier, or a group of the formula: --NR.sup.1 R.sup.2, wherein R.sup.1 is hydrogen atom, methyl group or ethyl group, and R.sup.2 is an atomic group satisfying that the value of log P, in which P is a distribution coefficient in a water-octanol system, of a compound of the formula: R.sup.2 H is from 0 to 3.2, the group being bonded to the carrier, and a method for removing a serum amyloid protein from body fluid through a removing apparatus using the above adsorbent. According to the present invention, SA proteins, particularly SAA proteins and SAP proteins can be selectively removed from body fluid without decreasing HDL largely. Besides, the adsorbent can be provided at a low cost.
REFERENCES:
patent: 4100149 (1978-07-01), Meiller
patent: 4782014 (1988-11-01), Serban
Pepys et al, 105 Clin. Chem. ACTA 83-82 (1980) (Abstract).
Ku et al, 158 J. Exp. Med. 767-780 (1983) (Abstract).
Kato et al, 31 Jikeikai Med. J. 165-167 (Abstract).
Parker et al, 9 Biochem. 1074-1082 (1970).
Ortega et al, Chemical Abstracts 102:44057c (1985).
Hirai Fumiyasu
Tani Nobutaka
Kanegafuchi Kagaku Kogyo & Kabushiki Kaisha
Rollins John W.
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