Adsorbent for serum amyloid protein

Details Adsorbent for serum amyloid protein Adsorbent for serum amyloid protein

1992-09-22

2000-03-14

Wax, Robert A.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Separation or purification

530380, 530413, 530416, 530417, 604 5, A23J 100, A61K 3514, A61M 3700

Patent

active

060374586

ABSTRACT:
An adsorbent for a serum amyloid protein, which comprises a water-insoluble carrier and either a compound selected from the group consisting of a compound having an anionic functional group, a polyanionic compound having more than one anionic functional groups, aniline and an aniline derivative, said compound being immobilized onto said carrier, or a group of the formula: --NR.sup.1 R.sup.2, wherein R.sup.1 is hydrogen atom, methyl group or ethyl group, and R.sup.2 is an atomic group satisfying that the value of log P, in which P is a distribution coefficient in a water-octanol system, of a compound of the formula: R.sup.2 H is from 0 to 3.2, said group being bonded to said carrier, and a method for removing a serum amyloid protein from body fluid through a removing apparatus using the above adsorbent. According to the present invention, SA proteins, particularly SAA proteins and SAP proteins can be selectively removed from body fluid without decreasing HDL largely. Besides, the adsorbent can be provided at a low cost.

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