Adsorbent for adsorbing organic compounds adsorbed on proteins

Details Adsorbent for adsorbing organic compounds adsorbed on proteins Adsorbent for adsorbing organic compounds adsorbed on proteins

1978-06-22

1980-05-13

Castel, Benoit

Liquid purification or separation

Particulate material type separator, e.g., ion exchange or...

Within flow line or flow line connected closed casing

210DIG23, 521 29, 521 38, 424 79, B01D 1504

Patent

active

042027756

ABSTRACT:
An adsorbent comprising a porous copolymer produced by copolymerizing a cross-linkable monomer and a mono-ethylenically unsaturated monomer, said copolymer having pores of an average pore diameter (d) of 500 A to 6,000 A and having such a broad pore diameter distribution that the pore volume having a pore diameter in the range of from 0.5 d to 2 d is not more than 60% of the total pore volume in the copolymer. By the use of such a porous copolymer having a specific composition and pore characteristics, organic compounds (e.g. toxic compounds) adsorbed on the proteins (e.g. plasma proteins) present in intercellular and/or extracellular liquids (e.g. blood) can be effectively adsorption-removed. Especially when the present adsorbent is used for purification of blood, it is advantageously subjected to such a pretreatment that plasma proteins are adsorbed on the adsorbent and then crosslinked with a crosslinking agent. The pretreated adsorbent can prevent unfavorable adsorption of blood platelets and leukocytes thereon. The present adsorbent is quite suitable for use in a column type purifier apparatus.

REFERENCES:
patent: 3531463 (1970-09-01), Gustafson
patent: 3663467 (1972-05-01), Albright
patent: 3794584 (1974-02-01), Kunin
patent: 4064042 (1977-12-01), Kunin

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