Drug – bio-affecting and body treating compositions – Identification or warning feature – Taste or smell or chemical irritation to the eye – nose – or...
Patent
1987-02-18
1989-10-31
Robinson, Douglas W.
Drug, bio-affecting and body treating compositions
Identification or warning feature
Taste or smell or chemical irritation to the eye, nose, or...
424684, 514811, 514823, A61K 3306
Patent
active
048776017
DESCRIPTION:
BRIEF SUMMARY
This invention relates to compositions which assist in the removal of alcohol from human systems.
The problem of lowering alcohol content from a human being particularly in the blood is one which has received considerable attention without any great success in solving the problem.
Alcohol can remain in the blood for many hours after original ingestion. Various factors influence the level of blood alcohol found after the ingestion of alcoholic beverages and alcohol-containing foods. These include:- response to prior ingestion of alcohol. emotional state. seems to vary widely according to individual circumstances. Injudicious consumption of alcohol leads to a demand for products capable of reducing its concentration in the body, for example, (a) to conform with "drink-and-drive" legislation, (b) to avert hangovers, or (c) in medical emergencies.
Proposals have been made to accelerate the metabolism of the alcohol so as to lead to early removal from the system. However, biologically active compounds have proved either ineffective or erratic and unpredictable. Thus fructose is believed to accelerate the metabolism of ethanol and compositions containing either fructose or sucrose have been suggested. The ingredients of one such product, on sale in the USA, are declared as: vitamin C; spirulina micro algae, papaya powder, fructose, caffeine, cayenne pepper, binding agents. The most popular ingredients of such products in general include vitamins and fructose, both of which have been shown in specific circumstances to produce the desired effect. The effectiveness of these has been challenged. Even to the extent that some effectiveness has been shown, it is erratic and extremely personal as to whether an individual will in fact find a lowering of alcohol as a result of ingestion of fructose. At best, the results achieved are highly variable and therefore inadequate for the requirements. Further disadvantages of such products are their side-effects, for example the heavy calorie load of fructoe at the recommended dose. Alcohol-degrading enzymes have been considered, but rejected because degradation products, such as aceteldehyde, tend to be more toxic than alcohol itself.
Absorbing systems have been suggested such as charcoal. Here again, however, any evidence indicates either little or no effect or very unpredictable effect. Part of the problem with charcoal is that it tends not to be specific in its absorption and there is interference from other materials in the stomach and intestine some of which either prevent absorption of alcohol or result in release of alcohol once absorbed.
Generally speaking because of the very complex nature of the contents of the intestines it is believed that a simple physical absorption system would not be likely to give satisfactory or predictable absorption of alcohol sufficient to lower the alcohol content in the blood. Moreover there was no reason to believe that simple absorption from the stomach contents might affect the presence of alcohol elsewhere in the human body.
It has now been surprisingly found that one particular type of absorbent does effectively lower the body content of alcohol particularly the alcohol content of the blood and to do so on a predictable basis.
In the present invention therefore there is provided a composition in edible form which contains a physiologically inert hydrophobic molecular sieve material, particularly a crystallne zeolite, which has a pore size such as to permit the absorption of ethanol but the exclusion of other organic materials present in the blood or intestines. Such zeolites have hitherto been known as industrial materials. For ingestion they would have to be prepared in a form suitable for administration for example by dispersion in an edible or physiologically acceptable base and particularly in dosage unit form having regard to the amount of alcohol to be absorbed. The invention also encompasses a method of producing a medicament comprising said zeolite for the purpose of administration to a human being to counteract the effects o
REFERENCES:
patent: 4537771 (1985-08-01), Greb et al.
patent: 4627972 (1986-12-01), Gioffre et al.
Synthesis of High-Silica Aluminosilicate Zeolites Jacobs et al., Studies in Surface Science and Catalysis, vol. 33, pp. 103-106, 1987.
"Zeolites as Adsorbents for Alcohols from Aqueous Solutions", Haegh, Zeolites .COPYRGT.1985, pp. 605-609.
Henley III Raymond J.
Robinson Douglas W.
Watney Combe Reid & Truman Limited
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