Liquid purification or separation – With means to add treating material – Chromatography
Reexamination Certificate
2006-03-07
2010-11-23
Menon, Krishnan S (Department: 1797)
Liquid purification or separation
With means to add treating material
Chromatography
C210S656000, C252S521100
Reexamination Certificate
active
07837872
ABSTRACT:
An adsorption apparatus comprising a column filled with an adsorbent, wherein the surface of the adsorbent and its vicinity mainly comprise an apatite which is represented by the formula (Ca1-aMa)10(PO4)6((OH)1-bXb)2, where the M represents at least one kind of rare earth metal elements, the X represents at least one kind of halogen elements, 0<a≦1, and 0≦b≦1. Preferably, the M comprises a lanthanide-based metal element mainly comprising Sm, and the ratio of Sm is no less than 70% to the total amount of the M. The adsorbent apparatus may be manufactured by passing a solution containing ions of at least one kind of rare earth metal elements through the adsorbent filling space of the column filled with the apatite represented by the formula Ca10(PO4)6((OH)1-bXb)2, where the X represents at least one kind of halogen elements and 0≦b≦1.
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English Language Abstract of JP 8-211041.
Suen et al., “Hydroxyapatite-based immobilized metal affinity adsorbents for protein purification,” Journal of Chromatography A, vol. 1048, pp. 31-39 (2004).
Nordstrom et al., “Generation of a new protein purification matrix by loading ceramic hydroxyapatite with metal ions—demonstration with poly-histidine tagged green fluorescent protein,” Journal of Biotechnology, vol. 69, pp. 125-133 (1999).
U.S. Appl. No. 10/560,077 to Kobayashi et al., filed Dec. 9, 2005.
Kobayashi Shintaro
Masuzawa Naomi
Okuyama Tsuneo
Yoshitake Tomohiko
Greenblum & Bernstein P.L.C.
Hoya Corporation
Menon Krishnan S
Okuyama Tsuneo
Zalasky Katherine
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