Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Reexamination Certificate
2005-10-26
2011-10-11
Tsang, Cecilia J (Department: 1654)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
C514S021400, C514S021300, C530S324000, C530S326000, C530S327000, C530S413000
Reexamination Certificate
active
08034785
ABSTRACT:
The present invention provides a peptide which selectively adsorbs an anti-β1 adrenoreceptor antibody being one of the contributing factors in dilated cardiomyopathy. The peptide of the invention can be immobilized on a carrier in a short period of time with rarely inducing side reactions, and adsorbent for adsorbing an anti-β1 adrenoreceptor antibody can be produced with good efficiency by using the peptide. In addition, the present invention provides an adsorbent comprising such peptide immobilized on a carrier, an adsorber wherein such adsorbent is used, and a method for adsorbing an anti-β1 adrenoreceptor antibody. The adsorbent and adsorber according to the invention can efficiently deprive an anti-β1 adrenoreceptor antibody-containing liquid, in particular body fluid, of the antibody.
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L. Sun et al., “Generation of an affinity column for antibody purification by intein-mediated protein ligation” Journal of Immunological Methods, vol. 282, No. 1-2, pp. 45-52, (2003).
Hanita Sakiko
Nishimoto Takehiro
Ogino Eiji
Ohara Kazumasa
Connolly Bove & Lodge & Hutz LLP
Gudibande Satyanarayana
Kaneka Corporation
Tsang Cecilia J
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